Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.
about
Splicing therapy for neuromuscular diseaseOxidative Stress Triggers Body-Wide Skipping of Multiple Exons of the Spinal Muscular Atrophy GeneA short antisense oligonucleotide ameliorates symptoms of severe mouse models of spinal muscular atrophyA multi-exon-skipping detection assay reveals surprising diversity of splice isoforms of spinal muscular atrophy genes.ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy.Targeting SR proteins improves SMN expression in spinal muscular atrophy cells.Advances in therapeutic development for spinal muscular atrophy.Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: evidence for involvement of splicing regulatory proteins.Disease mechanisms and therapeutic approaches in spinal muscular atrophy.Frequency of SMN1 deletion carriers in a Mestizo population of central and northeastern Mexico: A pilot study.Antisense-based therapy for the treatment of spinal muscular atrophySplicing regulation in spinal muscular atrophy by an RNA structure formed by long-distance interactions.Mechanistic principles of antisense targets for the treatment of spinal muscular atrophyThe pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.An intronic structure enabled by a long-distance interaction serves as a novel target for splicing correction in spinal muscular atrophySpinal muscular atrophy: an update on therapeutic progressAntisense oligonucleotide mediated therapy of spinal muscular atrophyMouse models of SMA: tools for disease characterization and therapeutic development.Diverse role of survival motor neuron protein.Faulty RNA splicing: consequences and therapeutic opportunities in brain and muscle disorders.How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophyHypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse modelActivation of a cryptic 5' splice site reverses the impact of pathogenic splice site mutations in the spinal muscular atrophy gene.Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.A Multilayered Control of the Human Survival Motor Neuron Gene Expression by Alu Elements.Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes.
P2860
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P2860
Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
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name
Alternative splicing in spinal ...... of an intron definition model.
@ast
Alternative splicing in spinal ...... of an intron definition model.
@en
type
label
Alternative splicing in spinal ...... of an intron definition model.
@ast
Alternative splicing in spinal ...... of an intron definition model.
@en
prefLabel
Alternative splicing in spinal ...... of an intron definition model.
@ast
Alternative splicing in spinal ...... of an intron definition model.
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P2860
P356
P1433
P1476
Alternative splicing in spinal ...... of an intron definition model.
@en
P2093
Natalia N Singh
Ravindra N Singh
P2860
P304
P356
10.4161/RNA.8.4.16224
P577
2011-07-01T00:00:00Z