The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid
about
Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513General anaesthetic actions on ligand-gated ion channelsGABA A receptors: subtypes provide diversity of function and pharmacologyInternational Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. UpdateThe anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulatorMolecular targets underlying general anaesthesiaPharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptorsMutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2Neurosteroids: endogenous regulators of the GABA(A) receptorMapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogueThe actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutationsA novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188Effects of gamma-HCH and delta-HCH on human recombinant GABA(A) receptors: dependence on GABA(A) receptor subunit combinationTwo gamma2L subunit domains confer low Zn2+ sensitivity to ternary GABA(A) receptorsγ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptorsMutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsFragrant dioxane derivatives identify beta1-subunit-containing GABAA receptorsPoint mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gatingHow we recall (or don't): the hippocampal memory machine and anesthetic amnesiaPropofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavitiesLearning and memory during sleep and anesthesia.Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actionsPhotoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activityMolecular and functional diversity of the expanding GABA-A receptor gene family.Induced changes in protein receptors conferring resistance to anesthetics.New insights into the mechanism of action of hypnotics.Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia.Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptorsEthanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans.Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibitionFlavonoid modulation of GABA(A) receptors.A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis.Clinical and molecular pharmacology of etomidate.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.
P2860
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P2860
The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The interaction of the general ...... luenced by a single amino acid
@ast
The interaction of the general ...... luenced by a single amino acid
@en
The interaction of the general ...... luenced by a single amino acid
@nl
type
label
The interaction of the general ...... luenced by a single amino acid
@ast
The interaction of the general ...... luenced by a single amino acid
@en
The interaction of the general ...... luenced by a single amino acid
@nl
prefLabel
The interaction of the general ...... luenced by a single amino acid
@ast
The interaction of the general ...... luenced by a single amino acid
@en
The interaction of the general ...... luenced by a single amino acid
@nl
P2093
P2860
P3181
P356
P1476
The interaction of the general ...... luenced by a single amino acid
@en
P2093
J A Peters
J J Lambert
P J Whiting
P2860
P304
P3181
P356
10.1073/PNAS.94.20.11031
P407
P577
1997-09-30T00:00:00Z