Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity
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Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsCorrection for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA ReceptorsKavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular MechanismA Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)Clinical and molecular pharmacology of etomidate.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors.Etomidate uniquely modulates the desensitization of recombinant α1β3δ GABA(A) receptors.The Direct Actions of GABA, 2'-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries.2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors.Mutations in the GABAA receptor that mimic the allosteric ligand etomidate.Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptorsγ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor.Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptorsStructural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.New insights into the molecular mechanisms of general anaesthetics.Monod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate.Orthosteric- versus allosteric-dependent activation of the GABAA receptor requires numerically distinct subunit level rearrangements.Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes.The expanding genetic toolkit for exploring mechanisms of general anesthesia.p-Coumaric acid activates the GABA-A receptor in vitro and is orally anxiolytic in vivo.Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.Alphaxalone Binds in Inner Transmembrane β+-α- Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors.The pharmacogenetics of medications used in general anesthesia.Comparison of αβδ and αβγ GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.Analysis of γ-aminobutyric acid (GABA) type A receptor subtypes using isosteric and allosteric ligands.
P2860
Q28544412-9521CBED-5511-4025-854B-84EB8AC6CD05Q28551559-B1ED7E3C-3AE3-47F5-9DBB-BAE349FDB841Q34531667-18F3B795-04A6-4510-8881-1965F797B0ABQ34661183-95FC2F13-0F09-4560-8BAA-CF5F359C2FC4Q35024852-D3A9C465-E72F-42CD-AF27-C8725EB07EA3Q35024917-49C911B8-44BA-441A-B4C4-9A4A2FFF2DB2Q35052026-8556C76D-FB24-4F4D-89C7-DD26C5A434A6Q35682320-35B5F0E1-E338-4AC2-983B-9687E7445457Q35794756-2E05DC17-49F6-4A8E-ADCF-A38DB23A351BQ35819211-9C5B1C95-46E5-40AD-8750-4DC6B1C11DC8Q35853220-666A6C8D-F70B-4377-A246-D7C0821B3133Q35853243-6E4553ED-3415-4A7B-9CAE-A81293B78395Q35988566-D76BFEF1-1584-4D2C-9F1A-CA6C2A2820C3Q36005514-75A941CA-B02E-4434-9212-0DDD89A49BE3Q36378031-3DC4E793-34F8-4D22-9361-4DB5AC0CCCD0Q36716721-FDB5A6B3-03FF-43D0-95F1-4472D7BCC951Q36852531-AC49FCAC-0B0D-4C10-80BB-BBC14DF317CBQ37234043-8FB6009D-27FA-4178-A280-401AF2FF5724Q37648115-014D1E90-F99C-41B7-92E0-7DB912F2222CQ37782116-35AD6593-712A-4445-901A-C2B15A2A6A1CQ38011975-7F8B397A-741C-4A65-A542-749CBE2BC97BQ38629698-9DFFA3FA-FB25-4E04-A639-1877DF8A784CQ41108241-4363A4AE-B362-4E61-8541-EEEC09B07912Q42708032-2CA1E7DD-700D-4BF0-A97C-979BD04FA078Q45056941-888B750D-89E8-4A3E-8B83-8021748CC18FQ46102112-24BBB32C-9F38-474C-B785-A84E8376B002Q46287845-B9C808F4-012C-4FD9-B091-AD8A722BE88DQ47213395-0191CD31-692F-4E03-8750-39DD8376007CQ47215880-4A01F28D-145D-4539-AE40-61262B2636AAQ48663996-1D5CF0A3-B2E9-434A-8102-0D88B8D6A1C3
P2860
Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Gamma-amino butyric acid type ...... and agonist-dependent activity
@ast
Gamma-amino butyric acid type ...... and agonist-dependent activity
@en
Gamma-amino butyric acid type ...... nd agonist-dependent activity.
@nl
type
label
Gamma-amino butyric acid type ...... and agonist-dependent activity
@ast
Gamma-amino butyric acid type ...... and agonist-dependent activity
@en
Gamma-amino butyric acid type ...... nd agonist-dependent activity.
@nl
prefLabel
Gamma-amino butyric acid type ...... and agonist-dependent activity
@ast
Gamma-amino butyric acid type ...... and agonist-dependent activity
@en
Gamma-amino butyric acid type ...... nd agonist-dependent activity.
@nl
P2093
P2860
P1433
P1476
Gamma-amino butyric acid type ...... and agonist-dependent activity
@en
P2093
Dirk Ruesch
Rooma Desai
Stuart A Forman
P2860
P304
P356
10.1097/ALN.0B013E3181B55FAE
P407
P577
2009-10-01T00:00:00Z