Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
about
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recyclingRAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskSORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processesLysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutationMembrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5Role of the Retromer Complex in Neurodegenerative DiseasesThe endosomal-lysosomal system: from acidification and cargo sorting to neurodegenerationThe retromer complex in development and diseaseThe retromer complex - endosomal protein recycling and beyondThe synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degenerationSorting through the roles of beclin 1 in microglia and neurodegenerationThe retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degenerationNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingA molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complexDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseRetromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in DrosophilaCargo trafficking in Alzheimer’s disease: the possible role of retromerHuntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neuronsSorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's diseaseGenetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics.The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transportIsolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability.The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.Genomic Comparison of Indigenous African and Northern European Chickens Reveals Putative Mechanisms of Stress Tolerance Related to Environmental Selection PressureACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.Transgenic Drosophila models of Alzheimer's disease and tauopathiesPharmacological chaperones stabilize retromer to limit APP processing.A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.Polyamine pathway contributes to the pathogenesis of Parkinson disease.Evolution and diversity of the Golgi.Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Retromer: a master conductor of endosome sorting.Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.Dysregulation of protein trafficking in neurodegeneration.BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.Physiology and pathology of endosome-to-Golgi retrograde sorting.VPS35 mutations in Parkinson diseaseThe role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation
P2860
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P2860
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Retromer deficiency observed i ...... ration, and Abeta accumulation
@ast
Retromer deficiency observed i ...... ration, and Abeta accumulation
@en
Retromer deficiency observed i ...... ration, and Abeta accumulation
@nl
type
label
Retromer deficiency observed i ...... ration, and Abeta accumulation
@ast
Retromer deficiency observed i ...... ration, and Abeta accumulation
@en
Retromer deficiency observed i ...... ration, and Abeta accumulation
@nl
prefLabel
Retromer deficiency observed i ...... ration, and Abeta accumulation
@ast
Retromer deficiency observed i ...... ration, and Abeta accumulation
@en
Retromer deficiency observed i ...... ration, and Abeta accumulation
@nl
P2093
P2860
P921
P3181
P356
P1476
Retromer deficiency observed i ...... ration, and Abeta accumulation
@en
P2093
Agnieszka Staniszewski
Alim Muhammad
Barry Ganetzky
Emmanuel Planel
Hong Zhang
Ingrid Flores
Lawrence S Honig
Lingling Ho
Mathieu Herman
Robert Kreber
P2860
P304
P3181
P356
10.1073/PNAS.0802545105
P407
P577
2008-05-20T00:00:00Z