Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
about
Chaperone-mediated autophagy: molecular mechanisms and physiological relevanceInterplay of LRRK2 with chaperone-mediated autophagyGlycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)Chaperone-mediated autophagy: a unique way to enter the lysosome worldAging as an event of proteostasis collapsemTOR: from growth signal integration to cancer, diabetes and ageingPeroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophyProtein homeostasis and aging: taking care of proteins from the cradle to the graveInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondRedox control of protein degradationYou're only as old as your arteries: translational strategies for preserving vascular endothelial function with agingAutophagy, nutrition and immunologyThe role of autophagy in the pathogenesis of diabetic nephropathyMitochondrial and skeletal muscle health with advancing ageAutophagy and agingAutophagy and apoptosis in liver injuryNew insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heartMitophagy: mechanisms, pathophysiological roles, and analysisMitochondria and the autophagy-inflammation-cell death axis in organismal agingEmerging novel concept of chaperone therapies for protein misfolding diseasesRoles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degenerationTargeting autophagy for the treatment of liver diseasesAge effect on myocellular remodeling: response to exercise and nutrition in humansAn engineering approach to extending lifespan in C. elegansCrystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyxAutophagy and cardiovascular aging: lesson learned from rapamycin.Autophagy regulates sphingolipid levels in the liverThe hallmarks of agingRapalogs and mTOR inhibitors as anti-aging therapeuticsAging and immune function: molecular mechanisms to interventionsAUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effectsIKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cellsLAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon diseaseOxidation of survival factor MEF2D in neuronal death and Parkinson's diseaseLong-term IGF-I exposure decreases autophagy and cell viability.Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liverLysosomal degradation of alpha-synuclein in vivo.The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.
P2860
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P2860
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Restoration of chaperone-media ...... intenance and hepatic function
@ast
Restoration of chaperone-media ...... intenance and hepatic function
@en
Restoration of chaperone-media ...... intenance and hepatic function
@nl
type
label
Restoration of chaperone-media ...... intenance and hepatic function
@ast
Restoration of chaperone-media ...... intenance and hepatic function
@en
Restoration of chaperone-media ...... intenance and hepatic function
@nl
prefLabel
Restoration of chaperone-media ...... intenance and hepatic function
@ast
Restoration of chaperone-media ...... intenance and hepatic function
@en
Restoration of chaperone-media ...... intenance and hepatic function
@nl
P2860
P3181
P356
P1433
P1476
Restoration of chaperone-media ...... intenance and hepatic function
@en
P2093
Cong Zhang
P2860
P2888
P304
P3181
P356
10.1038/NM.1851
P407
P577
2008-09-01T00:00:00Z
P5875
P6179
1024658664