mTOR: from growth signal integration to cancer, diabetes and ageing - Test2 - elhamkhani - TriplyDB

mTOR: from growth signal integration to cancer, diabetes and ageing

mTOR: from growth signal integration to cancer, diabetes and ageing

http://www.wikidata.org/entity/Q24633662

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Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma The crosstalk of mTOR/S6K1 and Hedgehog pathways Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12 FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth The effects of testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: differential effects on high-androgen responder and low-androgen responder muscle groups Regulation of TOR by small GTPases Lessons from C. elegans: signaling pathways for longevity Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells Links between metabolism and cancer State of the science: an update on renal cell carcinoma Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders Wnt5a Signaling in Cancer The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance The organization and regulation of mRNA-protein complexes Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function The Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal Cancer The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR Unexploited Antineoplastic Effects of Commercially Available Anti-Diabetic Drugs The mTOR pathway in obesity driven gastrointestinal cancers: Potential targets and clinical trials Regulation of liver development: implications for liver biology across the lifespan Staphylococcal Superantigens Spark Host-Mediated Danger Signals 5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications Olive Oil and the Hallmarks of Aging Live strong and prosper: the importance of skeletal muscle strength for healthy ageing PI3K/Akt/mTOR inhibitors in breast cancer The Autophagic Machinery in Enterovirus Infection Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?Erythropoietin and diabetes mellitus Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up Characterizing autism spectrum disorders by key biochemical pathways.Autophagy signal transduction by ATG proteins: from hierarchies to networks

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mTOR: from growth signal integration to cancer, diabetes and ageing

http://www.wikidata.org/entity/Q24633662

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

mTOR: from growth signal integration to cancer, diabetes and ageing

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mTOR: from growth signal integration to cancer, diabetes and ageing

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mTOR: from growth signal integration to cancer, diabetes and ageing

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mTOR: from growth signal integration to cancer, diabetes and ageing

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mTOR: from growth signal integration to cancer, diabetes and ageing

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mTOR: from growth signal integration to cancer, diabetes and ageing

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mTOR: from growth signal integration to cancer, diabetes and ageing

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mTOR: from growth signal integration to cancer, diabetes and ageing

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mTOR: from growth signal integration to cancer, diabetes and ageing

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Nature Reviews Molecular Cell Biology

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mTOR: from growth signal integration to cancer, diabetes and ageing

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Roberto Zoncu

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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21-35

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scholarly article

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336613

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10.1038/NRM3025

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1

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12

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David M Sabatini

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2010-12-15T00:00:00Z

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49682824

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1025226207

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21157483

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3390257

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