Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction - Test2 - elhamkhani - TriplyDB

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction

http://www.wikidata.org/entity/Q24656085

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Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications Illicit dopamine transients: reconciling actions of abused drugs Subunit Stabilization and Polyethylene Glycolation of Cocaine Esterase Improves In Vivo Residence Time The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors Decreased reinforcing effects of cocaine following 2 weeks of continuous D-amphetamine treatment in rats.Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling.Evidence for noncompetitive modulation of substrate-induced serotonin release.Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications.Assessment of receptor occupancy-over-time of two dopamine transporter inhibitors by [(11)C]CIT and target controlled infusion Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection.Gender differences in zebrafish responses to cocaine withdrawal Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters.Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction Monoamine transporters: vulnerable and vital doorkeepers.Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis.Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives.The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse Hypothesis-driven medication discovery for the treatment of psychostimulant addiction Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.Long-acting Preparations in Substance Abuse Management: A Review and Update.miR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells.Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter Daily monitoring of dopamine efflux reveals a short-lasting occlusion of the dopamine agonist properties of d-amphetamine by dopamine transporter blockers GBR 12909 and methylphenidate.The dopamine uptake inhibitor 3 alpha-[bis(4'-fluorophenyl)metoxy]-tropane reduces cocaine-induced early-gene expression, locomotor activity, and conditioned reward.Target-directed discovery and production of pharmaceuticals in transgenic mutant plant cells.CTDP-32476: A Promising Agonist Therapy for Treatment of Cocaine Addiction.Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking.The behavioral pharmacology and therapeutic potential of lorcaserin for substance use disorders.Comparison of the MK-801-induced increase in non-rewarded appetitive responding with dopamine agonists and locomotor activity in rats.The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.

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P2860

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction

http://www.wikidata.org/entity/Q24656085

description

2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2008 թվականի հունվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Dopamine transport inhibitors ...... ons to treat cocaine addiction

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Dopamine transport inhibitors ...... ons to treat cocaine addiction

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Dopamine transport inhibitors ...... ons to treat cocaine addiction

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type

label

Dopamine transport inhibitors ...... ons to treat cocaine addiction

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Dopamine transport inhibitors ...... ons to treat cocaine addiction

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Dopamine transport inhibitors ...... ons to treat cocaine addiction

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Dopamine transport inhibitors ...... ons to treat cocaine addiction

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Dopamine transport inhibitors ...... ons to treat cocaine addiction

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Dopamine transport inhibitors ...... ons to treat cocaine addiction

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J.BCP.2007.08.007

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Biochemical Pharmacology

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Dopamine transport inhibitors ...... ons to treat cocaine addiction

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Michael H Baumann

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Richard B Rothman

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Thomas E Prisinzano

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P2860

Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin

2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy

The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates

Vanoxerine National Institute on Drug Abuse

A tolerance study of single and multiple dosing of the selective dopamine uptake inhibitor GBR 12909 in healthy subjects

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation

Limbic activation during cue-induced cocaine craving

Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents

Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.

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10.1016/J.BCP.2007.08.007

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Amy Hauck Newman

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