The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors
about
Modafinil as a catecholaminergic agent: empirical evidence and unanswered questionsAddiction-related gene regulation: risks of exposure to cognitive enhancers vs. other psychostimulantsR-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuseA practical guide to the therapy of narcolepsy and hypersomnia syndromesPharmacotherapy for stimulant-related disordersBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesModafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatumPositron Emission Tomography (PET) and Graphical Kinetic Data Analysis of the Dopamine Neurotransmitter System: An Exercise for an Undergraduate Laboratory CourseTreatment with modafinil and escitalopram, alone and in combination, on cocaine-induced effects: a randomized, double blind, placebo-controlled human laboratory study.Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate.Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analoguesPractical use and risk of modafinil, a novel waking drug.Assessing the roles of stimulants/stimulant-like drugs and dopamine-agonists in the treatment of bipolar depression.Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease.Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamineDopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinitiesNovel C-1 substituted cocaine analogs unlike cocaine or benztropine.Importance of cholesterol in dopamine transporter function.Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine UptakeMolecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transportZinc for treating of children and adolescents with attention-deficit hyperactivity disorder: a systematic review of randomized controlled clinical trials.Sites of action of sleep and wake drugs: insights from model organisms.Computational modeling of human dopamine transporter structures, mechanism and its interaction with HIV-1 transactivator of transcription.Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease.Use of Stimulants in Bipolar Disorder.Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells.Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.The role of human dopamine transporter in NeuroAIDS.Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.The unique psychostimulant profile of (±)-modafinil: investigation of behavioral and neurochemical effects in mice.Overview of Monoamine Transporters.Functional properties of dopamine transporter oligomers after copper linking.The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.Modafinil Dependence: A Case with Attention-Deficit/Hyperactivity Disorder.Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes.Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter.
P2860
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P2860
The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
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2011年論文
@zh-hk
2011年論文
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2011年論文
@zh-tw
2011年论文
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name
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@ast
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@en
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@nl
type
label
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@ast
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@en
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@nl
prefLabel
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@ast
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@en
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@nl
P2860
P921
P3181
P1433
P1476
The atypical stimulant and noo ...... ssical cocaine-like inhibitors
@en
P2093
Kyle C Schmitt
Maarten E A Reith
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0025790
P407
P577
2011-01-01T00:00:00Z