Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
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Aneuploidy: cancer's fatal flaw?The role of aneuploidy in promoting and suppressing tumorsAutosomal dominant polycystic kidney disease: the last 3 yearsDancing genomes: fungal nuclear positioningAneuploidy in stem cellsThe cilia-regulated proteasome and its role in the development of ciliopathies and cancerLinks between mutant p53 and genomic instabilityYeast: a simple model system to study complex phenomena of aneuploidyAneuploidy and drug resistance in pathogenic fungiUnisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformansAneuploidy-induced cellular stresses limit autophagic degradation.Single-cell sequencing reveals karyotype heterogeneity in murine and human malignanciesA System to Study Aneuploidy In VivoIdentification of aneuploidy-tolerating mutationsElevated tolerance to aneuploidy in cancer cells: estimating the fitness effects of chromosome number alterations by in silico modelling of somatic genome evolutionUnique features of the transcriptional response to model aneuploidy in human cellsAcquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistanceReprogramming to pluripotency can conceal somatic cell chromosomal instabilityNeocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans ChromosomePrinciples of cancer therapy: oncogene and non-oncogene addictionAneuploidy Causes Non-genetic IndividualityHigh levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability.A new permanent cell line derived from the bank vole (Myodes glareolus) as cell culture model for zoonotic viruses.How do human cells react to the absence of mitochondrial DNA?Aneuploidy and improved growth are coincident but not causal in a yeast cancer model.Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.Proteomic changes resulting from gene copy number variations in cancer cellsWhole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.History, molecular mechanisms, and endoscopic treatment of Barrett's esophagus.Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer.Chromosomal instability confers intrinsic multidrug resistance.BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).Mechanisms and consequences of aneuploidy and chromosome instability in the aging brainNuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer.DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies.
P2860
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P2860
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@ast
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@en
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@nl
type
label
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@ast
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@en
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@nl
prefLabel
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@ast
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@en
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@nl
P2093
P2860
P3181
P356
P1433
P1476
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
@en
P2093
Bret R Williams
Charles A Whittaker
Christina M Glazier
David E Housman
Karen E Hunter
Vineet R Prabhu
P2860
P3181
P356
10.1126/SCIENCE.1160058
P407
P577
2008-10-31T00:00:00Z