High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells. - Test2 - elhamkhani - TriplyDB

High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.

High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.

http://www.wikidata.org/entity/Q30499296

about

Characterization of a putative spindle assembly checkpoint kinase Mps1, suggests its involvement in cell division, morphogenesis and oxidative stress tolerance in Candida albicans Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Characterization of novel MPS1 inhibitors with preclinical anticancer activity Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer The MPS1 family of protein kinases.Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy The latest progress in research on triple negative breast cancer (TNBC): risk factors, possible therapeutic targets and prognostic markers Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells.Mining novel effector proteins from the esophageal gland cells of Meloidogyne incognita.TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.Expression and function analysis of mitotic checkpoint genes identifies TTK as a potential therapeutic target for human hepatocellular carcinoma.Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells.Highly informative marker sets consisting of genes with low individual degree of differential expression.Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.A new genome-driven integrated classification of breast cancer and its implications.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.The gene expression landscape of breast cancer is shaped by tumor protein p53 status and epithelial-mesenchymal transition.Mps1 kinase regulates tumor cell viability via its novel role in mitochondria Modulation of miR-21 signaling by MPS1 in human glioblastoma TTK is a favorable prognostic biomarker for triple-negative breast cancer survival.Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer.Genetic instability: tipping the balance.Triple-negative breast cancer: investigating potential molecular therapeutic target.Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma.Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.Molecular characterization of breast cancer cell lines through multiple omic approaches.Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.Mps1 is SUMO-modified during the cell cycle.Molecular basis underlying resistance to Mps1/TTK inhibitors.TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunity.Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers.MPS1 kinase as a potential therapeutic target in medulloblastoma.Threonine and tyrosine kinase may serve as a prognostic biomarker for gallbladder cancer.

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P2860

High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.

http://www.wikidata.org/entity/Q30499296

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

High levels of the Mps1 checkp ...... ploidy in breast cancer cells.

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High levels of the Mps1 checkp ...... ploidy in breast cancer cells.

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type

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High levels of the Mps1 checkp ...... ploidy in breast cancer cells.

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High levels of the Mps1 checkp ...... ploidy in breast cancer cells.

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High levels of the Mps1 checkp ...... ploidy in breast cancer cells.

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High levels of the Mps1 checkp ...... ploidy in breast cancer cells.

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PNAS.1007645108

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Proceedings of the National Academy of Sciences of the United States of America

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High levels of the Mps1 checkp ...... ploidy in breast cancer cells.

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Edward Gabrielson

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Jewel Daniel

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Ju-Hyung Woo

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Kathleen Wilsbach

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P2860

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

Mutations of mitotic checkpoint genes in human cancers

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

Genetic instability of cancer cells is proportional to their degree of aneuploidy

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

Gene expression profiling predicts clinical outcome of breast cancer

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5384-5389

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scholarly article

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10.1073/PNAS.1007645108

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108

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Jonathan Coulter

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3069188

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