Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase - Test2 - elhamkhani - TriplyDB

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

http://www.wikidata.org/entity/Q24658087

about

TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain Direct activation of protein kinases by unanchored polyubiquitin chains Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expres PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL Ubc13: the Lys63 ubiquitin chain building machine Deconstructing innate immune signaling in myelodysplastic syndromes Linear ubiquitination signals in adaptive immune responses Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1 Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1.HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination.Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation.A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.Emerging complexity of protein ubiquitination in the NF-κB pathway.Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta Polyubiquitin binding to ABIN1 is required to prevent autoimmunity.Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex.MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4.Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF.Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signaling MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation.IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.Role of non-degradative ubiquitination in interleukin-1 and toll-like receptor signaling.ABIN1 dysfunction as a genetic basis for lupus nephritis.Ubiquitin in NF-kappaB signaling.Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.

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Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

http://www.wikidata.org/entity/Q24658087

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Molecular and Cellular Biology

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Interleukin-1 (IL-1) induces t ...... ivation of IkappaBalpha kinase

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Margaret Stafford

http://www.w3.org/2001/XMLSchema#string

Mark Peggie

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Mark Windheim

http://www.w3.org/2001/XMLSchema#string

Philip Cohen

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P2860

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

Characterization of Pellino2, a substrate of IRAK1 and IRAK4

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway

IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)

Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

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1783-91

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scholarly article

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4303368

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10.1128/MCB.02380-06

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5

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28

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2008-03-01T00:00:00Z

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5670635

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18180283

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2258775

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