Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence - Test2 - elhamkhani - TriplyDB

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

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Alcoholism: A Systems Approach From Molecular Physiology to Addictive Behavior Neuropharmacology of alcohol addiction Nalmefene: a new approach to the treatment of alcohol dependence Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action A role for brain stress systems in addiction.Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse.Dynorphin--still an extraordinarily potent opioid peptide A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans Effect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areas Don't stress about CRF: assessing the translational failures of CRF1antagonists.Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors.Effects of stress on alcohol drinking: a review of animal studies.Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors Nalmefene for the treatment of alcohol use disorders: recent data and clinical potential.The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction.Operant alcohol self-administration in dependent rats: focus on the vapor model Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior Potent inhibition of alcohol self-administration in alcohol-preferring rats by a κ-opioid receptor antagonist Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes Acamprosate and naltrexone treatment effects on ethanol and sucrose seeking and intake in ethanol-dependent and nondependent rats The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse Schedule of passive ethanol exposure affects subsequent intragastric ethanol self-infusion Neurobiology of dysregulated motivational systems in drug addiction.Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation.Opioid modulators for alcohol dependence.Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.Opioid receptors and the discriminative stimulus effects of ethanol in squirrel monkeys: Mu and delta opioid receptor mechanisms Safety, tolerability, and pharmacokinetic evaluation of single- and multiple-ascending doses of a novel kappa opioid receptor antagonist LY2456302 and drug interaction with ethanol in healthy subjects.Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050.Neurobiology of addiction: a neurocircuitry analysis.PET imaging reveals sex differences in kappa opioid receptor availability in humans, in vivo The epigenetic landscape of alcoholism.Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems

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Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

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Brendan M Walker

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George F Koob

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Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses

Missing data: our view of the state of the art

Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?

Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens

Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens

An opponent-process theory of motivation: I. Temporal dynamics of affect.

Drug abuse: hedonic homeostatic dysregulation

Drug addiction, dysregulation of reward, and allostasis

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats

Multiple imputation: a primer.

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