The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse - Test2 - elhamkhani - TriplyDB

The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse

The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse

http://www.wikidata.org/entity/Q33890721

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Natural rewards, neuroplasticity, and non-drug addictions Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis.Nalmefene: a new approach to the treatment of alcohol dependence 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse Medications development for opioid abuse κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction Role of kappa-opioid receptors in stress and anxiety-related behavior.Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence.The multiple facets of opioid receptor function: implications for addiction Multiple roles for orexin/hypocretin in addiction Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs.Kappa Opioids, Salvinorin A and Major Depressive Disorder Molecular mechanisms of synaptic remodeling in alcoholism The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats The role of motivation and reward neural systems in vocal communication in songbirds Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys.Direct targeting of peptidergic amygdalar neurons by noradrenergic afferents: linking stress-integrative circuitry Central effects of ethanol interact with endogenous mu-opioid activity to control isolation-induced analgesia in maternally separated infant rats.Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity Reduced emotional signs of opiate withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake μ-Opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation.Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in cocaine dependence Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress.Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of substance use and related disorders. Part 2: Opioid dependence.Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.The effects of amphetamine, butorphanol, and their combination on cocaine self-administration.Identification of novel functionally selective κ-opioid receptor scaffolds.Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain.Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse.Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting".Nitric oxide and histone deacetylases modulate cocaine-induced mu-opioid receptor levels in PC12 cells.Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns.

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The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse

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2010 nî lūn-bûn

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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George F Koob

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Sunmee Wee

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P2860

Striatal and ventral pallidum dynorphin concentrations are markedly increased in human chronic cocaine users

Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

Kappa opioids as potential treatments for stimulant dependence

A role for brain stress systems in addiction.

Dynorphin, stress, and depression

The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses

Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system

U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking

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