Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
about
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondriaBax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondriaBcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimersInteraction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosisBAD is a pro-survival factor prior to activation of its pro-apoptotic functionBcl-x(L) retrotranslocates Bax from the mitochondria into the cytosolProapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activationThe vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein BaxInteraction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascadesSpatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosisSmall-Molecule Bcl2 BH4 Antagonist for Lung Cancer TherapyBim: a novel member of the Bcl-2 family that promotes apoptosisEnforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosisDEDD, a novel death effector domain-containing protein, targeted to the nucleolusConformation of the Bax C-terminus regulates subcellular location and cell deathMutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arseniteThe bacterial redox protein azurin induces apoptosis in J774 macrophages through complex formation and stabilization of the tumor suppressor protein p53.Hsp27 as a negative regulator of cytochrome C release.Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status.G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasisHumanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient miceInsig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosisCeramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cellsAn internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathwayProapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activityMovement of Bax from the cytosol to mitochondria during apoptosisInhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondriaEvidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanismThe structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activityResistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase geneApoptosis: targets in pancreatic cancerRegulation of Bim in Health and DiseasePhotoreceptor cell death and rescue in retinal detachment and degenerationsBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreMicroglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cellsBAX activation is initiated at a novel interaction siteStructural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 DomainA1/Bfl-1 in leukocyte development and cell deathPescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells
P2860
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P2860
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@ast
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@en
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@nl
type
label
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@ast
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@en
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@nl
prefLabel
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@ast
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@en
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@nl
P2093
P2860
P3181
P356
P1476
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.94.8.3668
P407
P577
1997-04-15T00:00:00Z