Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
about
tBid undergoes multiple conformational changes at the membrane required for Bax activationA novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathwaysThe mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c releaseMaspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteinsIntegration and oligomerization of Bax protein in lipid bilayers characterized by single molecule fluorescence studyStructural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 DomainStructure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 EpitopeBuilding blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosisSynthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survivalBcl-XL inhibits membrane permeabilization by competing with Bax.Unravelling the bcl-2 apoptosis code with a simple model system.Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid.FLIP protects against hypoxia/reoxygenation-induced endothelial cell apoptosis by inhibiting Bax activationBax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis.Bax forms an oligomer via separate, yet interdependent, surfaces.The cytosolic domain of Fis1 binds and reversibly clusters lipid vesicles.The rheostat in the membrane: BCL-2 family proteins and apoptosisBcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motifBcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated BaxROS production is essential for the apoptotic function of E2F1 in pheochromocytoma and neuroblastoma cell lines.Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanismsReconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax proteinFusion-competent state induced by a C-terminal HIV-1 fusion peptide in cholesterol-rich membranes.Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.Groundnut bud necrosis virus encoded NSm associates with membranes via its C-terminal domain.PKD1 protein is involved in reactive oxygen species-mediated mitochondrial depolarization in cooperation with protein kinase Cδ (PKCδ).Cytotoxic effects and the mechanism of three types of magnetic nanoparticles on human hepatoma BEL-7402 cellsIdentification of Bax-voltage-dependent anion channel 1 complexes in digitonin-solubilized cerebellar granule neuronsHeat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation.The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External RegionSmall molecules reveal an alternative mechanism of Bax activation.An interconnected hierarchical model of cell death regulation by the BCL-2 familyMitochondria: pharmacological manipulation of cell deathBH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranesDirect and selective small-molecule activation of proapoptotic BAXEmbedded together: the life and death consequences of interaction of the Bcl-2 family with membranes.Mechanisms of action of Bcl-2 family proteins
P2860
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P2860
Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Interaction with a membrane su ...... ed with induction of apoptosis
@ast
Interaction with a membrane su ...... ed with induction of apoptosis
@en
Interaction with a membrane su ...... ed with induction of apoptosis
@en-gb
Interaction with a membrane su ...... ed with induction of apoptosis
@nl
type
label
Interaction with a membrane su ...... ed with induction of apoptosis
@ast
Interaction with a membrane su ...... ed with induction of apoptosis
@en
Interaction with a membrane su ...... ed with induction of apoptosis
@en-gb
Interaction with a membrane su ...... ed with induction of apoptosis
@nl
prefLabel
Interaction with a membrane su ...... ed with induction of apoptosis
@ast
Interaction with a membrane su ...... ed with induction of apoptosis
@en
Interaction with a membrane su ...... ed with induction of apoptosis
@en-gb
Interaction with a membrane su ...... ed with induction of apoptosis
@nl
P2093
P2860
P356
P1476
Interaction with a membrane su ...... ed with induction of apoptosis
@en
P2093
Brian Leber
Jeremy A Yethon
Raquel F Epand
Richard M Epand
P2860
P304
P356
10.1074/JBC.M306289200
P407
P577
2003-12-05T00:00:00Z