RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist - Test2 - elhamkhani - TriplyDB

RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

http://www.wikidata.org/entity/Q24672108

about

The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro Understanding migraine: Potential role of neurogenic inflammation Larvae of the small white butterfly, Pieris rapae, express a novel serotonin receptor The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice Physiology of meningeal innervation: aspects and consequences of chemosensitivity of meningeal nociceptors.Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.Motoneuron excitability and muscle spasms are regulated by 5-HT2B and 5-HT2C receptor activity.Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.Therapies in development for the treatment of migraine.C4 phenyl aporphines with selective h5-HT(2B) receptor affinity A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030.A systematic investigation of the differential roles for ventral tegmentum serotonin 1- and 2-type receptors on food intake in the rat.Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology.A unique phenotype of 5-HT2C, agonist-induced GTPgamma35S binding, transferable to 5-HT2A and 5-HT2B, upon swapping intracellular regions.Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes.5-Hydroxytryptamine receptor assays.5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats.α2- and β2-Adrenoreceptor-Mediated Efficacy of the Atypical Antidepressant Agomelatine Combined With Gabapentin to Suppress Allodynia in Neuropathic Rats With Ligated Infraorbital or Sciatic Nerve.

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P2860

RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

http://www.wikidata.org/entity/Q24672108

description

1999 nî lūn-bûn

@nan

1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի հուլիսին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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type

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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British Journal of Pharmacology

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RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist

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P2093

A Webber

http://www.w3.org/2001/XMLSchema#string

C Rocha

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D W Bonhaus

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E Leung

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G R Martin

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K Van Natta

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L A Flippin

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L K Chang

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M Dawson

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R J Greenhouse

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P2860

The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors

5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells

Functional evidence for a 5-HT2B receptor mediating contraction of longitudinal muscle in human small intestine

Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle

In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin)

Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor

Cloning and functional characterization of the human 5-HT2B serotonin receptor

Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences

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1075-82

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scholarly article

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567089

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10.1038/SJ.BJP.0702632

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5

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127

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10455251

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1566110

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