A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity - Test2 - elhamkhani - TriplyDB

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

http://www.wikidata.org/entity/Q24673016

about

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus Therapeutic targeting of Janus kinases Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease Role of type I interferons in the activation of autoreactive B cells Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome TYK2 kinase activity is required for functional type I interferon responses in vivo Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.The molecular regulation of Janus kinase (JAK) activation New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis.A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence Regulation and function of IL-17A- and IL-22-producing γδ T cells.Targeting the Jak/STAT pathway for immunosuppression.A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12 Janus kinase 3: the controller and the controlled A new modality for immunosuppression: targeting the JAK/STAT pathway.In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.Progress in multiple sclerosis genetics.Parsing the Interferon Transcriptional Network and Its Disease Associations T cell-directed therapies: lessons learned and future prospects.Cytokine regulation of immunopathology in toxoplasmosis.Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.Molecular markers of susceptibility to ocular toxoplasmosis, host and guest behaving badly.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases Targeting signaling pathways with small molecules to treat autoimmune disorders.Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012.Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers.Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis.Therapeutic potential of tyrosine kinase 2 in autoimmunity.Primary Immunodeficiencies with Elevated IgE.Genetic susceptibility to rheumatoid arthritis and its implications for novel drug discovery.Tyrosine kinase 2 controls IL-1ß production at the translational level.Protective role of naturally occurring interleukin-17A-producing γδ T cells in the lung at the early stage of systemic candidiasis in mice.

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A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

http://www.wikidata.org/entity/Q24673016

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2003 nî lūn-bûn

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2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2003年の論文

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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Proceedings of the National Academy of Sciences of the United States of America

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A natural mutation in the Tyk2 ...... to infection and autoimmunity

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George S Yap

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Josiane Ragimbeau

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Victor Boyartchuk

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William F Dietrich

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P2860

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis

A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection

Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation

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Sandra Pellegrini

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2003-09-30T00:00:00Z

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9087652

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14500783

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