Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice - Test2 - elhamkhani - TriplyDB

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

http://www.wikidata.org/entity/Q24673105

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Transmissible Spongiform Encephalopathies Affecting Humans Treatment of Prion Disease with Heterologous Prion Proteins Thermodynamic Stabilization of the Folded Domain of Prion Protein Inhibits Prion Infection in Vivo Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease.Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein.Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures.Convection-enhanced delivery of AAV2-PrPshRNA in prion-infected mice Mouse neuronal cells expressing exogenous bovine PRNP and simultaneous downregulation of endogenous mouse PRNP using siRNAs.Expression of prion protein in mouse erythroid progenitors and differentiating murine erythroleukemia cells.Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents Lentiviral-mediated silencing of farnesyl pyrophosphate synthase through RNA interference in mice.Insights into prion biology: integrating a protein misfolding pathway with its cellular environment.Role of MicroRNA in Visceral Pain.Recent advances in prion chemotherapeutics.The cellular prion protein (PrP(C)): its physiological function and role in disease Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.Progress on RNAi-based molecular medicines.Therapeutic approaches for prion disorders.Prion-like propagation of protein aggregation and related therapeutic strategies.Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticles.Lentiviral delivery of short hairpin RNAs Therapy for prion diseases: Insights from the use of RNA interference.Therapeutic interventions ameliorating prion disease.Antisense gene silencing: therapy for neurodegenerative disorders?Lentiviral vector-mediated gene transfer and RNA silencing technology in neuronal dysfunctions.Patented biological approaches for the therapeutic modulation of the 37 kDa/67 kDa laminin receptor.RNAi: a potential new class of therapeutic for human genetic disease.Modelling neurodegeneration in prion disease - applications for drug development.Small RNA drugs for prion disease: a new frontier.Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress.RNA-based drugs and vaccines.Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay.Insights from Therapeutic Studies for PrP Prion Disease.Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.Efficient knockdown of human prnp mRNA expression levels using hybrid hammerhead ribozymes.Lentivirus-mediated RNA interference targeting E2F-1 inhibits human gastric cancer MGC-803 cell growth in vivo.RNAi: a novel strategy for the treatment of prion diseases.Dual MicroRNA to Cellular Prion Protein Inhibits Propagation of Pathogenic Prion Protein in Cultured Cells.

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P2860

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

http://www.wikidata.org/entity/Q24673105

description

2006 nî lūn-bûn

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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

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Journal of Clinical Investigation

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Lentivector-mediated RNAi effi ...... vival of scrapie-infected mice

@en

P2093

Alexander Pfeifer

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Andreas Hofmann

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Gerda Mitteregger

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Hans Kretzschmar

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Markus Moser

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Saba Al-Khadra

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Sabina Eigenbrod

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Uwe Bertsch

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P2860

A single siRNA suppresses fatal encephalitis induced by two different flaviviruses.

A system for stable expression of short interfering RNAs in mammalian cells

Mice devoid of PrP are resistant to scrapie

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

Novel proteinaceous infectious particles cause scrapie

Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos.

Harnessing HIV for therapy, basic research and biotechnology.

Silence of the genes.

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.

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10.1172/JCI29236

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12

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116

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17143329

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Prion protein family

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