Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization - Test2 - elhamkhani - TriplyDB

Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization

Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization

http://www.wikidata.org/entity/Q24674862

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Genomic landscape of megakaryopoiesis and platelet function defects Transcription factors in late megakaryopoiesis and related platelet disorders Quantitative histological image analyses of reticulin fibers in a myelofibrotic mouse Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.Role for MKL1 in megakaryocytic maturation.Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes.The effect of amifostine on differentiation of the human megakaryoblastic Dami cell line.Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice.New roles for cyclin E in megakaryocytic polyploidization.The incredible journey: From megakaryocyte development to platelet formation.A central role for TRPS1 in the control of cell cycle and cancer development.Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase.Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice.Normal and malignant megakaryopoiesis.Erythroid and megakaryocytic transformation.miR-125b modulates megakaryocyte maturation by targeting the cell-cycle inhibitor p19INK4D.microRNA regulation in megakaryocytopoiesis.Anaplasma phagocytophilum infection modulates expression of megakaryocyte cell cycle genes through phosphatidylinositol-3-kinase signaling Expression of cyclin D1 after treatment with doxorubicin in the HL-60 cell line.Role of tumor suppressor p53 in megakaryopoiesis and platelet function.p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin.CDC6 expression is regulated by lineage-specific transcription factor GATA1.System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia.In vivo magnetic resonance imaging of a mouse model of myelofibrosis.Small Molecule Supplements Improve Cultured Megakaryocyte Polyploidization by Modulating Multiple Cell Cycle Regulators.Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.Isomer-specific effects of conjugated linoleic acid on proliferative activity of cultured neural progenitor cells.Chloroform fraction of Serratulae chinensis S. Moore suppresses proliferation and induces apoptosis via the phosphatidylinositide 3-kinase/Akt pathway in human gastric cancer cells.Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation

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Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization

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2007 nî lūn-bûn

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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2007年の論文

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Andrew G Muntean

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John D Crispino

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Liyan Pang

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Mortimer Poncz

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P2860

X-linked thrombocytopenia caused by a novel mutation of GATA-1

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

Growth suppression by p16ink4 requires functional retinoblastoma protein

The retinoblastoma protein and cell cycle control

CDK inhibitors: positive and negative regulators of G1-phase progression

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase

The regulation of E2F by pRB-family proteins

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12

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