The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding - Test2 - elhamkhani - TriplyDB

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

http://www.wikidata.org/entity/Q24675149

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Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells Effect of cancer-associated mutations in the PlexinB1 gene Structure and function of the intracellular region of the plexin-b1 transmembrane receptor Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG Signaling from axon guidance receptors Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 Modeling transmembrane domain dimers/trimers of plexin receptors: implications for mechanisms of signal transmission across the membrane Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain A Dual Binding Mode for RhoGTPases in Plexin Signalling Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization Functional regulation of semaphorin receptors by proprotein convertases Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF The activity of the plexin-A1 receptor is regulated by Rac Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.Plexin-B1 mutations in prostate cancer.A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer.Plexin-B1 activates NF-κB and IL-8 to promote a pro-angiogenic response in endothelial cells Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement.Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury To move or not to move? Semaphorin signalling in cell migration.Structural mechanisms of plexin signaling Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive.The role of semaphorin 4D in tumor development and angiogenesis in human breast cancer.Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning.Regulation and physiological functions of G12/13-mediated signaling pathways.1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold.Axon growth and guidance: receptor regulation and signal transduction Transmembrane semaphorins: Multimodal signaling cues in development and cancer.Rho and Ras GTPases in axon growth, guidance, and branching.The role of semaphorins and their receptors in platelets: Lessons learned from neuronal and immune synapses.Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly.Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.Molecular Dynamics Simulations Reveal Isoform Specific Contact Dynamics between the Plexin Rho GTPase Binding Domain (RBD) and Small Rho GTPases Rac1 and Rnd1.ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.Semaphorin 4D activates the MAPK pathway downstream of plexin-B1.Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain.

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The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

http://www.wikidata.org/entity/Q24675149

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2002 nî lūn-bûn

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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2002 թվականի ապրիլին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@ast

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@en

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@nl

type

label

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@ast

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@en

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@nl

prefLabel

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@ast

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@en

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

@nl

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Genes & Development

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The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

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Haris G Vikis

http://www.w3.org/2001/XMLSchema#string

Kun-Liang Guan

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Weiquan Li

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P2860

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway

Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension

The molecular biology of axon guidance

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila.

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila.

Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation.

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3335046

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10.1101/GAD.966402

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7

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16

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11427820

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11937491

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186329

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