High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations
about
An atomic-level mechanism for activation of the kinesin molecular motors.ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanismForce generation by kinesin and myosin cytoskeletal motor proteinsGenetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegansAltered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutantElectrostatically biased binding of kinesin to microtubulesStructure-based molecular simulations reveal the enhancement of biased Brownian motions in single-headed kinesinNonlinearity of mechanochemical motions in motor proteinsReversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin-microtubule interface.The beginning of kinesin's force-generating cycle visualized at 9-A resolutionStructural model for strain-dependent microtubule activation of Mg-ADP release from kinesinStructure of the Kinesin13-Microtubule Ring ComplexStructure and Functional Role of Dynein's Microtubule-Binding DomainA Common Substrate Recognition Mode Conserved between Katanin p60 and VPS4 Governs Microtubule Severing and Membrane Skeleton ReorganizationInsight into the molecular mechanism of the multitasking kinesin-8 motorConformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy.The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5Crystal structure of the Kar3-like kinesin motor domain from the filamentous fungus Ashbya gossypiiStructure of a kinesin-tubulin complex and implications for kinesin motilityStructural basis of interprotofilament interaction and lateral deformation of microtubules.Direct observation of the binding state of the kinesin head to the microtubule.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular MachinesA cool look at the structural changes in kinesin motor domainsMotor neuron synapse and axon defects in a C. elegans alpha-tubulin mutant.TUBA1A mutations cause wide spectrum lissencephaly (smooth brain) and suggest that multiple neuronal migration pathways converge on alpha tubulins.Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations.A seesaw model for intermolecular gating in the kinesin motor proteinConserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generationRab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering.X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding.Visualisation of a kinesin-13 motor on microtubule end mimics.Three-dimensional structure of cytoplasmic dynein bound to microtubulesMotor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A.Structures of kinesin motor proteins.The translocation selectivity of the kinesins that mediate neuronal organelle transport.Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules.Key residues on microtubule responsible for activation of kinesin ATPase.Forces and Disease: Electrostatic force differences caused by mutations in kinesin motor domains can distinguish between disease-causing and non-disease-causing mutations.
P2860
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P2860
High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
High-resolution cryo-EM maps s ...... open and closed conformations
@ast
High-resolution cryo-EM maps s ...... open and closed conformations
@en
High-resolution cryo-EM maps s ...... open and closed conformations
@nl
type
label
High-resolution cryo-EM maps s ...... open and closed conformations
@ast
High-resolution cryo-EM maps s ...... open and closed conformations
@en
High-resolution cryo-EM maps s ...... open and closed conformations
@nl
prefLabel
High-resolution cryo-EM maps s ...... open and closed conformations
@ast
High-resolution cryo-EM maps s ...... open and closed conformations
@en
High-resolution cryo-EM maps s ...... open and closed conformations
@nl
P2860
P356
P1433
P1476
High-resolution cryo-EM maps s ...... open and closed conformations
@en
P2093
Masahide Kikkawa
Nobutaka Hirokawa
P2860
P304
P356
10.1038/SJ.EMBOJ.7601299
P407
P577
2006-09-20T00:00:00Z