about
Repurposing metformin: an old drug with new tricks in its binding pocketsA DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencingLoops govern SH2 domain specificity by controlling access to binding pocketsWDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocketA phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activationFour-alpha-helix bundle with designed anesthetic binding pockets. Part II: halothane effects on structure and dynamicsFour-alpha-helix bundle with designed anesthetic binding pockets. Part I: structural and dynamical analysesHigh-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformationsAsymmetric interactions in the adenosine-binding pockets of the MS2 coat protein dimerImplications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical functionAllosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket.A ligand-binding pocket in the dengue virus envelope glycoproteinThe Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding PocketThe crystal structures of Phascolopsis gouldii wild type and L98Y methemerythrins: structural and functional alterations of the O2 binding pocketCrystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocketThe three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligandsMalignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pocketsStructural adaptability in the ligand-binding pocket of the ecdysone hormone receptorA closed binding pocket and global destabilization modify the binding properties of an alternatively spliced form of the second PDZ domain of PTP-BLStructure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAPStructural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinaseDoubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by DeacylcortivazolAcylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pocketsPathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approachThe CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small moleculesThe Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQStructures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine ExpulsionThe IsdC Protein from Staphylococcus aureus Uses a Flexible Binding Pocket to Capture HemeAllophycocyanin trimer stability and functionality are primarily due to polar enhanced hydrophobicity of the phycocyanobilin binding pocketThe crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1Unique GTP-binding pocket and allostery of uridylate kinase from a gram-negative phytopathogenic bacteriumAnalysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC from Streptomyces venezuelaeA new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptorCrystal structure of dinitrogenase reductase-activating glycohydrolase (DraG) reveals conservation in the ADP-ribosylhydrolase fold and specific features in the ADP-ribose-binding pocketp38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational AnalysesThe 2.1 Å crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl-binding pocket for small branched acyl substratesFatty Acid- and Retinoid-binding Proteins Have Distinct Binding Pockets for the Two Types of CargoA 5' cytosine binding pocket in Puf3p specifies regulation of mitochondrial mRNAsStructure of an Odorant-Binding Protein from the Mosquito Aedes aegypti Suggests a Binding Pocket Covered by a pH-Sensitive “Lid”
P921
Q22250976-3C179E3B-19D7-4CCE-B061-B002E74C168CQ24295604-2799D0B2-CC2B-411E-9846-06BDDCDDF276Q24310120-8AF075AD-02B6-4AC0-9DC1-B9953D4A9A00Q24321162-FFEE8AB0-0AB3-4A63-B526-D884864AF6BDQ24534951-23349FA2-3CC3-4F3A-9E47-05706EDFDDDCQ24654927-CC0F5A1E-8345-47A7-81B8-FE88014644AEQ24655524-D4CF4247-93DA-4954-AAC0-1376F52EE0FBQ24655550-2F81027E-2808-43B1-BF06-E49A1B378BC9Q24676249-B0144423-58AE-4BBE-B08A-539FDBCEA371Q24802201-059B5D9E-212C-4552-ACC1-55F81A767600Q27026364-4A366B01-39D4-4312-98D9-FAD27D6F40CAQ27316788-A8C705A4-2592-4A06-B036-E3106C50762BQ27477685-8200C1CF-8AAB-4B2D-871E-C18694641611Q27488798-C1642A4E-ED79-4E5D-9E95-0637973D87E7Q27631996-9E36D44B-8C18-4618-9507-B3FDB05F24CEQ27640585-C12BB830-B1A4-4940-9205-3C555C75F5ABQ27641458-D53D660A-A218-40FB-9FE6-1835654CA674Q27641615-7E6A6129-1420-40C0-9736-5292F55F285AQ27642470-1F7113F0-95D2-487C-BC98-38DDFD39B58EQ27642946-D904A6B5-5CB3-4410-B99E-199ECE6D8D37Q27643977-2078731F-9590-4F1D-BA73-D7EAC080C88DQ27645128-B9F7DF8D-2A38-40E0-B17B-71E73F7EC1A4Q27649439-6FF5E6DB-BF73-49A3-A606-6DDC45210636Q27649443-53529297-32FD-404D-AB60-0BE035F3F7E9Q27649882-DE71F100-E5F7-49A1-AAA7-382BC6845E82Q27649904-7CBAC4E6-2560-46A1-A12F-99E2D45DE758Q27650463-28F69FFA-1D6A-4AD2-83F8-3D23FEC321C1Q27651360-6CB7D753-1672-4854-9D03-B5AE0E8A41C0Q27651717-5FDC295C-72A9-4AFE-A6EE-F9426C038049Q27652318-CAF938AC-BAD7-4D25-A107-BCC977224008Q27652882-C9EA362A-1B07-4036-ABB0-EA58928513BCQ27653065-E55A122C-6489-4B9A-ADF6-10DDFCB592C5Q27653345-3C0CE195-9AE6-451D-9A75-CEC735A30794Q27653647-2064D1F6-8F3A-4A32-B549-DC06BE2BA57BQ27655653-D374D713-3F98-4A94-BA31-15F2E26625EEQ27655779-803B648F-F134-497B-9742-62DD9BBBE39DQ27656125-26154BE9-1E47-4DC6-91EA-DCB0BE54D4ACQ27657785-17977D7D-E77F-4CA7-B8D5-61CEDC5DA7D4Q27658210-8CDEADCF-4372-4FAA-9AE8-61524DEE9683Q27658418-A0E45CD9-5F17-49FE-88CE-72736AA34F80
P921
description
part of a macromolecule involved in ligand binding
@en
name
binding pocket
@en
bindingslomme
@nn
type
label
binding pocket
@en
bindingslomme
@nn
prefLabel
binding pocket
@en
bindingslomme
@nn