Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone - Test2 - elhamkhani - TriplyDB

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

http://www.wikidata.org/entity/Q24681479

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Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Ral GTPases: crucial mediators of exocytosis and tumourigenesis Ral GTPases in tumorigenesis: emerging from the shadows Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms Synthesis of novel Ral inhibitors: An in vitro and in vivo study Discovery and characterization of small molecules that target the GTPase Ral The Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.Phosphorylation of RalB is important for bladder cancer cell growth and metastasis RalBP1 is necessary for metastasis of human cancer cell lines Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.ERBB2 increases metastatic potentials specifically in androgen-insensitive prostate cancer cells.Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance.Ral activation promotes melanomagenesis.Cediranib/AZD2171 inhibits bone and brain metastasis in a preclinical model of advanced prostate cancer.Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent.Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition.The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery.MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis.AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells.Inhibition of Ras for cancer treatment: the search continues.Mechanisms regulating colorectal cancer cell metastasis into liver (Review).Overexpression of RalBP1 in colorectal cancer is an independent predictor of poor survival and early tumor relapse PGE2 promotes renal carcinoma cell invasion through activated RalA.RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS Mouse models for studying prostate cancer bone metastasis.EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1.Androgen receptor regulates SRC expression through microRNA-203 KLF4 functions as an activator of the androgen receptor through reciprocal feedback.Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer.Contributions of KRAS and RAL in non-small-cell lung cancer growth and progression.The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.Activation and involvement of Ral GTPases in colorectal cancer.

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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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type

label

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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prefLabel

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

@ast

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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Molecular and Cellular Biology

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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

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Claire Pollock

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JuanJuan Yin

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Kathleen Kelly

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Michael Oberst

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Monika Chock

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Philip Martin

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P2860

The small GTPase RalA targets filamin to induce filopodia

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival.

RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity

Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

Gene expression profiling predicts clinical outcome of breast cancer

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

Genes that mediate breast cancer metastasis to lung

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

Dissemination and growth of cancer cells in metastatic sites

A multigenic program mediating breast cancer metastasis to bone

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10.1128/MCB.00955-07

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