The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor - Test2 - elhamkhani - TriplyDB

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

http://www.wikidata.org/entity/Q24682781

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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response Nedd4 controls animal growth by regulating IGF-1 signaling Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation Differential expression of novel potential regulators in hematopoietic stem cells.The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins Targeting the ubiquitin pathway for cancer treatment NEDD4: a promising target for cancer therapy Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4 Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase.Altered expression and deletion of RMO1 in osteosarcoma The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1 Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17 Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting Tissue-specific regulation and function of Grb10 during growth and neuronal commitment.Role of ubiquitination in IGF-1 receptor signaling and degradation.Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants.The UPS in diabetes and obesity.Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.Alterations in the developing testis transcriptome following embryonic vinclozolin exposure YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation.Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells.Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.Insulin-like growth factor-I E-peptide activity is dependent on the IGF-I receptor.Association study confirmed susceptibility loci with keloid in the Chinese Han population.

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The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

http://www.wikidata.org/entity/Q24682781

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2003 nî lūn-bûn

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2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2003 թվականի մայիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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label

The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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MCB.23.9.3363-3372.2003

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Molecular and Cellular Biology

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The Grb10/Nedd4 complex regula ...... -like growth factor I receptor

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Adriano Marchese

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Andrea Morrione

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Pauline Henry

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P2860

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14

Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF

The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2

Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

Role for the adaptor protein Grb10 in the activation of Akt

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3363-72

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3804814

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10.1128/MCB.23.9.3363-3372.2003

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9

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23

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Andrea Vecchione

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2003-05-01T00:00:00Z

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12697834

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protein ubiquitination

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153198

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