Mechanism of prion propagation: amyloid growth occurs by monomer addition
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The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenicDisaggregases, molecular chaperones that resolubilize protein aggregatesPrion-like polymerization as a signaling mechanismYeast prions: structure, biology, and prion-handling systemsTowards a Pharmacophore for AmyloidMolecular basis for amyloid- polymorphismAtomic structure and hierarchical assembly of a cross- amyloid fibrilYeast prions are useful for studying protein chaperones and protein quality controlRebels with a cause: molecular features and physiological consequences of yeast prionsNew insights into in vitro amyloidogenic properties of human serum albumin suggest considerations for therapeutic precautionsPrions as adaptive conduits of memory and inheritanceThe Hofmeister effect on amyloid formation using yeast prion proteinDiscovery of dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro studyThe drive to life on wet and icy worldsβ-sheet propensity controls the kinetic pathways and morphologies of seeded peptide aggregation.Ortho-methylated 3-hydroxypyridines hinder hen egg-white lysozyme fibrillogenesis.Prion amyloid structure explains templating: how proteins can be genes.Observation of spatial propagation of amyloid assembly from single nucleiRapid microtubule self-assembly kineticsOptical trapping with high forces reveals unexpected behaviors of prion fibrils.Mechanistic and environmental control of the prevalence and lifetime of amyloid oligomersSuper-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregatesPolymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide.Nanomaterials design and tests for neural tissue engineering.Routine fluorescence microscopy of single untethered protein molecules confined to a planar zone.Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities.Prion protein insertional mutations increase aggregation propensity but not fiber stability.Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress.Model discrimination and mechanistic interpretation of kinetic data in protein aggregation studies.Investigating the conformational stability of prion strains through a kinetic replication model.Stable polyglutamine dimers can contain β-hairpins with interdigitated side chains-but not α-helices, β-nanotubes, β-pseudohelices, or steric zippers.Role of small oligomers on the amyloidogenic aggregation free-energy landscapePrion diseases and their biochemical mechanisms.Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregationPrion dynamics and the quest for the genetic determinant in protein-only inheritanceEGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptidesRole for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Evaluating nuclei concentration in amyloid fibrillation reactions using back-calculation approach.
P2860
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P2860
Mechanism of prion propagation: amyloid growth occurs by monomer addition
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
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name
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@ast
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@en
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@nl
type
label
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@ast
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@en
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@nl
prefLabel
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@ast
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@en
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@nl
P2860
P3181
P1433
P1476
Mechanism of prion propagation: amyloid growth occurs by monomer addition
@en
P2093
Adam Douglass
Ronald D Vale
P2860
P3181
P356
10.1371/JOURNAL.PBIO.0020321
P407
P577
2004-10-01T00:00:00Z