Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation - Test2 - elhamkhani - TriplyDB

Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation

Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation

http://www.wikidata.org/entity/Q26269852

about

Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking Generation of induced neuronal cells by the single reprogramming factor ASCL1 Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons From "directed differentiation" to "neuronal induction": modeling neuropsychiatric disease Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students Forward engineering neuronal diversity using direct reprogramming An urgent need for experimental animal model of autism in drug development.In Situ Pluripotency Factor Expression Promotes Functional Recovery From Cerebral Ischemia Induced neuronal reprogramming.Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.Electrophysiological profiles of induced neurons converted directly from adult human fibroblasts indicate incomplete neuronal conversion.Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders.Probing disorders of the nervous system using reprogramming approaches.Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.The Human Model: Changing Focus on Autism Research.CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons.FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice.Modeling neurodevelopmental disorders using human pluripotent stem cells.Annual research review: The (epi)genetics of neurodevelopmental disorders in the era of whole-genome sequencing--unveiling the dark matter.In vivo reprogramming for tissue repair.New approaches for direct conversion of patient fibroblasts into neural cells.Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.Generation of pure GABAergic neurons by transcription factor programming.Direct conversion of human fibroblasts to functional excitatory cortical neurons integrating into human neural networks.Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned?Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells.Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening.Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy.The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons.Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression

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Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation

http://www.wikidata.org/entity/Q26269852

description

2013 nî lūn-bûn

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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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Proceedings of the National Academy of Sciences of the United States of America

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Neurons generated by direct co ...... sociated neuroligin-3 mutation

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P2860

Neuroligins and neurexins link synaptic function to cognitive disease

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice

Modelling schizophrenia using human induced pluripotent stem cells.

Direct conversion of fibroblasts to functional neurons by defined factors

Induced neuronal cells: how to make and define a neuron

Rapid single-step induction of functional neurons from human pluripotent stem cells

An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function

Induction of human neuronal cells by defined transcription factors

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