Conformational switch of syntaxin-1 controls synaptic vesicle fusion
about
Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapsesVps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomesMembrane fusion: grappling with SNARE and SM proteinsAnalysis of conditional heterozygous STXBP1 mutations in human neuronsSynaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic VesiclesNeurotransmitter release: the last millisecond in the life of a synaptic vesicleLipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter releaseUltrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situSyntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusionThe presynaptic active zoneSynaptic vesicle exocytosisRIM genes differentially contribute to organizing presynaptic release sitesCell biology of Ca2+-triggered exocytosisPiccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosisStructural and mutational analysis of functional differentiation between synaptotagmins-1 and -7Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosisMunc18-1 binding to the neuronal SNARE complex controls synaptic vesicle primingTesting the SNARE/SM protein model of membrane fusionELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapsesMolecular machines governing exocytosis of synaptic vesiclesSustaining rapid vesicular release at active zones: potential roles for vesicle tetheringPrinciples of allosteric interactions in cell signalingConformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegansPossible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formationThe Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering FactorsSyntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformationPrefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate.Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosisMunc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexPhosphorylation of syntaxin 3B by CaMKII regulates the formation of t-SNARE complexesRegulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clustersAn extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion.Syntaxin clusters assemble reversibly at sites of secretory granules in live cells.In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter releaseMunc18b is a major mediator of insulin exocytosis in rat pancreatic β-cellsQuantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography.How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.Secretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling in the cytoplasm of neuroendocrine cells.
P2860
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P2860
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@ast
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@en
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@nl
type
label
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@ast
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@en
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@nl
prefLabel
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@ast
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@en
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
@en
P2093
Alexander C Meyer
Heidi de Wit
Irina Dulubova
Jong-Cheol Rah
Robert E Hammer
Sang-Won Min
Stefan H Gerber
Xinran Liu
P2860
P304
P3181
P356
10.1126/SCIENCE.1163174
P407
P577
2008-09-12T00:00:00Z