Can residence time offer a useful strategy to target agonist drugs for sustained GPCR responses?

Can residence time offer a useful strategy to target agonist drugs for sustained GPCR responses?

Item
http://www.wikidata.org/entity/Q26801424
Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling.Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics.Estimation of kinetic and thermodynamic ligand-binding parameters using computational strategies.The Added Value of Assessing Ligand-Receptor Binding Kinetics in Drug Discovery.Impact of protein-ligand solvation and desolvation on transition state thermodynamic properties of adenosine A2A ligand binding kinetics.Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs.Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase.The Role of G Protein-coupled Receptor Kinases in Cancer.Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.Targeting GLP-1 receptor trafficking to improve agonist efficacy.
P2860

Can residence time offer a useful strategy to target agonist drugs for sustained GPCR responses?

Item
http://www.wikidata.org/entity/Q26801424
description
2016 nî lūn-bûn
@nan
2016 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Can residence time offer a use ...... for sustained GPCR responses?
@ast
Can residence time offer a use ...... for sustained GPCR responses?
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Can residence time offer a use ...... for sustained GPCR responses?
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type
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Can residence time offer a use ...... for sustained GPCR responses?
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Can residence time offer a use ...... for sustained GPCR responses?
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Can residence time offer a use ...... for sustained GPCR responses?
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prefLabel
Can residence time offer a use ...... for sustained GPCR responses?
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Can residence time offer a use ...... for sustained GPCR responses?
@en
Can residence time offer a use ...... for sustained GPCR responses?
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Can residence time offer a use ...... for sustained GPCR responses?
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10.1016/J.DRUDIS.2015.07.015
P407
P433
P478
P577
P698
P921