Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes - Test2 - elhamkhani - TriplyDB

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

http://www.wikidata.org/entity/Q26829985

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Current status and future prospects for enabling chemistry technology in the drug discovery process PubChem BioAssay: 2017 update Applications of chemogenomic library screening in drug discovery Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor.Epigenetic assays for chemical biology and drug discovery.Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.Advances in discovering small molecules to probe protein function in a systems context.Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay.Hallmarks of therapeutic management of the cystic fibrosis functional landscape.On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry.The Endocrine Society Centennial: Hormones and Apoptosis in the Prostate Gland… Live and Let Die Fold conservation and proteolysis in zebrafish IRBP structure: Clues to possible enzymatic function?Drugging Membrane Protein Interactions.Probes &Drugs portal: an interactive, open data resource for chemical biology.Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology.Whole animal HTS of small molecules for antifungal compounds.Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening.Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling.Research Resources for Nuclear Receptor Signaling Pathways.Academia-pharma partnerships for novel drug discovery: essential or nice to have?Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.Small molecules as therapeutic agents for inborn errors of metabolism.Non-kinase targets of protein kinase inhibitors.Fluorescence polarization assays in high-throughput screening and drug discovery: a review Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration-Approved Drugs.Unravelling biology and shifting paradigms in cancer with single-cell sequencing.Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.Integrated, Continuous Emulsion Creamer.DNA-Encoded Chemical Libraries: A Selection System Based On Endowing Organic Compounds with Amplifiable Information.Emerging Opportunities for Target Discovery in Rare Cancers.In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.A thiocyanopalladation/carbocyclization transformation identified through enzymatic screening: stereocontrolled tandem C-SCN and C-C bond formation.Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery.PubChem BioAssay: A Decade's Development toward Open High-Throughput Screening Data Sharing A Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-Distortion

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

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2015 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2015年の論文

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J.CELL.2015.05.023

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

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Alykhan F Shamji

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Andrea de Souza

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Anton Simeonov

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Beiyan Zou

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Benjamin F Cravatt

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Corey R Hopkins

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Craig W Lindsley

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Drug development: Raise standards for preclinical cancer research

Crystal structure of a lipid G protein-coupled receptor

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype

Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions

Drugs for allosteric sites on receptors

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

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