A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline - Test2 - elhamkhani - TriplyDB

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

http://www.wikidata.org/entity/Q22251083

about

Galactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer's disease Origins of amyloid-β Variant of TREM2 Associated with the Risk of Alzheimer's Disease Cerebrospinal fluid biomarkers of Alzheimer’s disease Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2 Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase In search of low-frequency and rare variants affecting complex traits Neural stem/progenitor cells in Alzheimer's disease The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy Genes associated with Alzheimer's disease: an overview and current status The amyloid hypothesis of Alzheimer's disease at 25 years Advances in development of fluorescent probes for detecting amyloid-β aggregates Endoplasmic Reticulum Stress and Associated ROS Suspected non-Alzheimer disease pathophysiology--concept and controversy Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia Genomic Discoveries and Personalized Medicine in Neurological Diseases Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease Fluid Biomarkers in Clinical Trials of Alzheimer's Disease Therapeutics The genetic landscape of Alzheimer disease: clinical implications and perspectives Autosomal Dominant Alzheimer Disease: A Unique Resource to Study CSF Biomarker Changes in Preclinical AD Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes Advances in Alzheimer's disease drug development Rare-variant association analysis: study designs and statistical tests Genome-scale neurogenetics: methodology and meaning Glutathione and mitochondria The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's disease Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotype Toward the structure of presenilin/γ-secretase and presenilin homologs Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways Bridging the gap between statistical and biological epistasis in Alzheimer's disease Mitochondrial glutathione: features, regulation and role in disease Synaptic dysfunction and septin protein family members in neurodegenerative diseases Exome sequencing and complex disease: practical aspects of rare variant association studies Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.Structural Conversion of Aβ17-42 Peptides from Disordered Oligomers to U-Shape Protofilaments via Multiple Kinetic Pathways Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

http://www.wikidata.org/entity/Q22251083

description

2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer's disease and age-related cognitive decline

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prefLabel

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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Amy Gustafson

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Janice Maloney

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Jasvinder K. Atwal

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Johanna Huttenlocher

http://www.w3.org/2001/XMLSchema#string

Jon Snaedal

http://www.w3.org/2001/XMLSchema#string

Kwame Hoyte

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Olafur T. Magnusson

http://www.w3.org/2001/XMLSchema#string

Palmi V. Jonsson

http://www.w3.org/2001/XMLSchema#string

Robert R. Graham

http://www.w3.org/2001/XMLSchema#string

Ryan J. Watts

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Global prevalence of dementia: a Delphi consensus study

APP processing in Alzheimer's disease

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

A new multipoint method for genome-wide association studies by imputation of genotypes

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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96-99

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535250

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10.1038/NATURE11283

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7409

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488

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Hreinn Stefansson

Unnur Þorsteinsdóttir

Daniel F Gudbjartsson

Ole A. Andreassen

Erik G Jönsson

Tushar Bhangale

Gyda Bjornsdottir

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2012-07-11T00:00:00Z

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1045345318

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22801501

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Alzheimer's disease