Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications
about
In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index.Epigenetic deregulations in chordoma.B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-κB.Drugging the Cancers Addicted to DNA Repair.Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach.Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage.Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donorThe histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathwaysLentivirus-mediated Knockdown of HDAC1 Uncovers Its Role in Esophageal Cancer Metastasis and Chemosensitivity.Histone modifications: Targeting head and neck cancer stem cells.Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases.Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages.A hybrid of thiazolidinone with the hydroxamate scaffold for developing novel histone deacetylase inhibitors with antitumor activities.How do tumor cells respond to HDAC inhibition?Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells.HDACs and HDAC Inhibitors in Cancer Development and Therapy.Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism.Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.HDAC5 promotes colorectal cancer cell proliferation by up-regulating DLL4 expressionCombination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer.Chromatin remodeling modulates radiosensitivity of the daughter cells derived from cell population exposed to low- and high-LET irradiation.Expression of LOC285758, a Potential Long Non-coding Biomarker, is Methylation-dependent and Correlates with Glioma Malignancy Grade.Effect of inhibiting Beclin-1 expression on autophagy, proliferation and apoptosis in colorectal cancer.The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells.Histone Deacetylase Inhibitor SAHA as Potential Targeted Therapy Agent for Larynx Cancer CellsHistone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53.Structure-activity relationships of hydroxamate-based histone deacetylase-8 inhibitors: reality behind anticancer drug discovery.Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors.Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors.Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors.p53-Mediated Molecular Control of Autophagy in Tumor Cells.TdIF1: a putative oncogene in NSCLC tumor progressionConcept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment
P2860
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P2860
Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications
description
2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Targeting histone deacetylases ...... nisms to clinical implications
@ast
Targeting histone deacetylases ...... nisms to clinical implications
@en
Targeting histone deacetylases ...... nisms to clinical implications
@nl
type
label
Targeting histone deacetylases ...... nisms to clinical implications
@ast
Targeting histone deacetylases ...... nisms to clinical implications
@en
Targeting histone deacetylases ...... nisms to clinical implications
@nl
prefLabel
Targeting histone deacetylases ...... nisms to clinical implications
@ast
Targeting histone deacetylases ...... nisms to clinical implications
@en
Targeting histone deacetylases ...... nisms to clinical implications
@nl
P2860
P3181
P356
P1476
Targeting histone deacetylases ...... nisms to clinical implications
@en
P2093
Wei-Guo Zhu
Zhiming Li
P2860
P304
P3181
P356
10.7150/IJBS.9067
P407
P577
2014-01-01T00:00:00Z
2014-07-02T00:00:00Z