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Endoreplication and polyploidy: insights into development and disease

Endoreplication and polyploidy: insights into development and disease

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Wound-Induced Polyploidy Is Required for Tissue Repair The Dark Side of Cell Fusion Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state of play Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts.Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability Identification of genes that are essential to restrict genome duplication to once per cell division Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability.Hormonal control of cell division and elongation along differentiation trajectories in roots.The MADS-box XAANTAL1 increases proliferation at the Arabidopsis root stem-cell niche and participates in transition to differentiation by regulating cell-cycle components.Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature More of a good thing or less of a bad thing: gene copy number variation in polyploid cells of the placenta Identification of mosaic and segmental aneuploidies by next-generation sequencing in preimplantation genetic screening can improve clinical outcomes compared to array-comparative genomic hybridization.CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer.Self-diploidization of human haploid parthenogenetic embryos through the Rho pathway regulates endomitosis and failed cytokinesis.Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines.Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal.Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells.Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models.Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans.Canonical Notch signalling is inactive in urothelial carcinoma.Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease.The expanding implications of polyploidy.Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage.Transcriptional repression by MYB3R proteins regulates plant organ growth.Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.p27(Kip1) participates in the regulation of endoreplication in differentiating chick retinal ganglion cells.Nutrient-Dependent Endocycling in Steroidogenic Tissue Dictates Timing of Metamorphosis in Drosophila melanogaster.Amiprophosmethyl-induced efficient in vitro production of polyploids in raphanobrassica with the aid of aminoethoxyvinylglycine (AVG) in the culture medium Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence.Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.The coordination of ploidy and cell size differs between cell layers in leaves.Making big cells: one size does not fit all.Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila.

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Endoreplication and polyploidy: insights into development and disease

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2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013年の論文

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Endoreplication and polyploidy: insights into development and disease

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Endoreplication and polyploidy: insights into development and disease

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D. T. Fox

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R. J. Duronio

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P2860

Endoreplication controls cell fate maintenance

Extreme polyploidy in a large bacterium

New insights into cell cycle control from the Drosophila endocycle

Hallmarks of Cancer: The Next Generation

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase

Endoreplication: polyploidy with purpose

The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles

Relationship between Endopolyploidy and Cell Size in Epidermal Tissue of Arabidopsis

Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells

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10.1242/DEV.080531

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3513989

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