Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells
about
Endoreplication and polyploidy: insights into development and diseaseDNA damage associated with mitosis and cytokinesis failureIntratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid stateHistone H3.3 maintains genome integrity during mammalian developmentGenetic evaluation of mesenchymal stem cells by G-banded karyotyping in a Cell Technology CenterNucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging.Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions.Mesenchymal stromal cells of osteosarcoma patients do not show evidence of neoplastic changes during long-term culture.Breast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state.Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during AnaphaseImmortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations.Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stressA three-state model of telomere control over human proliferative boundaries.Presence of a defect in karyokinesis during megakaryocyte endomitosisGenomic instability: Crossing pathways at the origin of structural and numerical chromosome changes.Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain developmentHow do telomeres and NHEJ coexist?The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation.The telomere deprotection response is functionally distinct from the genomic DNA damage response.Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice without Affecting Regeneration.Telomeres: Implications for Cancer Development.Telomere dysfunction and chromothripsis.GLUCAN SYNTHASE-LIKE8 and STEROL METHYLTRANSFERASE2 are required for ploidy consistency of the sexual reproduction system in Arabidopsis.Determinants and clinical implications of chromosomal instability in cancer.Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma.Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture.Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells.Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs
P2860
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P2860
Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells
description
2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@ast
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@en
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@nl
type
label
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@ast
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@en
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@nl
prefLabel
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@ast
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@en
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@nl
P2860
P3181
P1433
P1476
Progressive telomere dysfuncti ...... ccumulation of polyploid cells
@en
P2093
Anna Genescà
Cristina Frías
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1002679
P407
P577
2012-01-01T00:00:00Z