Design principles underpinning the regulatory diversity of protein kinases

Design principles underpinning the regulatory diversity of protein kinases

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http://www.wikidata.org/entity/Q27027644
Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailMolecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionHydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional SpecializationStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Molecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.Identification and classification of small molecule kinases: insights into substrate recognition and specificity.Tighter αC-helix-αL16-helix interactions seem to make p38α less prone to activation by autophosphorylation than Hog1.Structural and functional diversity in the activity and regulation of DAPK-related protein kinases.ProKinO: a unified resource for mining the cancer kinome.Small-world networks of residue interactions in the Abl kinase complexes with cancer drugs: topology of allosteric communication pathways can determine drug resistance effects.Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.From direct to indirect lithium targets: a comprehensive review of omics data.Network-based modelling and percolation analysis of conformational dynamics and activation in the CDK2 and CDK4 proteins: dynamic and energetic polarization of the kinase lobes may determine divergence of the regulatory mechanisms.Optogenetically controlled protein kinases for regulation of cellular signaling.
P2860

Design principles underpinning the regulatory diversity of protein kinases

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http://www.wikidata.org/entity/Q27027644
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2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
name
Design principles underpinning the regulatory diversity of protein kinases
@ast
Design principles underpinning the regulatory diversity of protein kinases
@en
Design principles underpinning the regulatory diversity of protein kinases
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Design principles underpinning the regulatory diversity of protein kinases
@ast
Design principles underpinning the regulatory diversity of protein kinases
@en
Design principles underpinning the regulatory diversity of protein kinases
@nl
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Design principles underpinning the regulatory diversity of protein kinases
@ast
Design principles underpinning the regulatory diversity of protein kinases
@en
Design principles underpinning the regulatory diversity of protein kinases
@nl
P1433
P1476
P2093
P275
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Design principles underpinning the regulatory diversity of protein kinases
@en
P2093
P275
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932