Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration
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Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastomaExternal push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membraneA YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancersSpatiotemporal control of cell signalling using a light-switchable protein interaction.Kinase AKT controls innate immune cell development and functionManipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biologySubcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration.Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosisRegulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulationNovel protein Callipygian defines the back of migrating cells.Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviourPolarization of migrating monocytic cells is independent of PI 3-kinase activityRac1-dependent lamellipodial motility in prostate cancer PC-3 cells revealed by optogenetic control of Rac1 activityComputational analysis of the spatiotemporal coordination of polarized PI3K and Rac1 activities in micro-patterned live cellsDetection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g.Signaling networks that regulate cell migrationProtein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxisInvasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism.Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxisDisruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones.Synthetic spatially graded Rac activation drives cell polarization and movement.The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblastsActin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophilsMammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeletonAn excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration.Rapidly reversible manipulation of molecular activity with dual chemical dimerizersCross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity.The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient.Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migrationCyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation.A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.Moving in the right direction: how eukaryotic cells migrate along chemical gradients.Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway.The signaling mechanisms underlying cell polarity and chemotaxisEvolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis.Gradient sensing in defined chemotactic fieldsSignaling pathways that control cell migration: models and analysisIn chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling.
P2860
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P2860
Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Synthetic activation of endoge ...... ell polarization and migration
@ast
Synthetic activation of endoge ...... ell polarization and migration
@en
Synthetic activation of endoge ...... ell polarization and migration
@nl
type
label
Synthetic activation of endoge ...... ell polarization and migration
@ast
Synthetic activation of endoge ...... ell polarization and migration
@en
Synthetic activation of endoge ...... ell polarization and migration
@nl
prefLabel
Synthetic activation of endoge ...... ell polarization and migration
@ast
Synthetic activation of endoge ...... ell polarization and migration
@en
Synthetic activation of endoge ...... ell polarization and migration
@nl
P2860
P1433
P1476
Synthetic activation of endoge ...... ell polarization and migration
@en
P2093
Takanari Inoue
Tobias Meyer
P2860
P356
10.1371/JOURNAL.PONE.0003068
P407
P577
2008-01-01T00:00:00Z