Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
about
Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseasesIsothermal microcalorimetry to study drugs against Schistosoma mansoniTRP channels in schistosomesRepurposing drugs for the treatment and control of helminth infectionsReprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseasesDrug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activatorComparative study of transcriptome profiles of mechanical- and skin-transformed Schistosoma mansoni schistosomulaWormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasitesRNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screeningStructural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoniMechanically produced schistosomula as a higher-throughput tools for phenotypic pre-screening in drug sensitivity assays: current research and future trendsDevelopment and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viabilityComparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screeningA novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motilityAntischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoniA novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous systemAn ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegansChemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis'Death and axes': unexpected Ca²⁺ entry phenologs predict new anti-schistosomal agentsIn silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoniAnalysis of nematode motion using an improved light-scatter based systemNovel Non-Peptide Inhibitors against SmCL1 of Schistosoma mansoni: In Silico Elucidation, Implications and Evaluation via Knowledge Based Drug DiscoveryActivity Profile of an FDA-Approved Compound Library against Schistosoma mansoniProlyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal InhibitorsHigh Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoniThe Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg DevelopmentA Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective InhibitorsStructure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoniThe identification of inhibitors of Schistosoma mansoni miracidial transformation by incorporating a medium-throughput small-molecule screenImage-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.Repositioning: the fast track to new anti-malarial medicines?The structural diversity and promise of antiparasitic marine invertebrate-derived small moleculesIdentification of G protein-coupled receptors in Schistosoma haematobium and S. mansoni by comparative genomics.The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterraneaQuantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis.In vitro and in vivo antischistosomal activity of ferroquine derivatives.Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoniFinding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib
P2860
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P2860
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Drug discovery for schistosomi ...... hroughput phenotypic screening
@ast
Drug discovery for schistosomi ...... hroughput phenotypic screening
@en
Drug discovery for schistosomi ...... hroughput phenotypic screening
@nl
type
label
Drug discovery for schistosomi ...... hroughput phenotypic screening
@ast
Drug discovery for schistosomi ...... hroughput phenotypic screening
@en
Drug discovery for schistosomi ...... hroughput phenotypic screening
@nl
prefLabel
Drug discovery for schistosomi ...... hroughput phenotypic screening
@ast
Drug discovery for schistosomi ...... hroughput phenotypic screening
@en
Drug discovery for schistosomi ...... hroughput phenotypic screening
@nl
P2093
P2860
P921
P3181
P1476
Drug discovery for schistosomi ...... hroughput phenotypic screening
@en
P2093
Brian Wolff
Conor R Caffrey
Debbie S Ruelas
Fengyun Xu
Janice Williams
June Snedecor
Kee-Chong Lim
Maha-Hamadien Abdulla
P2860
P3181
P356
10.1371/JOURNAL.PNTD.0000478
P407
P5008
P577
2009-07-14T00:00:00Z