Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium
about
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenaseSIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylaseAltering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic ProfilingMECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis DisorderRole of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.Implications of genomic signatures in the differential vulnerability to fetal alcohol exposure in C57BL/6 and DBA/2 mice4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial functionDefects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae.Thermal manipulation of the chicken embryo triggers differential gene expression in response to a later heat challengeMis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell deathAssembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesisLipoic acid biosynthesis defects.Induction of triglyceride accumulation and mitochondrial maintenance in muscle cells by lactate.Fatty Acid Biosynthesis Inhibition Increases Reduction Potential in Neuronal Cells under Hypoxia.Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase.The mitochondrial fatty acid synthesis (mtFASII) pathway is capable of mediating nuclear-mitochondrial cross talk through the PPAR system of transcriptional activationLipoic acid metabolism and mitochondrial redox regulation.Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia.Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease.Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice.Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation.Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes
P2860
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P2860
Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@ast
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@en
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@nl
type
label
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@ast
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@en
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@nl
prefLabel
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@ast
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@en
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@nl
P2093
P2860
P50
P3181
P1433
P1476
Compromised mitochondrial fatt ...... tion and energy disequilibrium
@en
P2093
Afshin Gharib
Andrzej Witkowski
Ayesha Moghul
Carling Cheung
Dejiang Feng
Frans Kuypers
Grace Wang
Hans Kristian Hannibal-Bach
Jennifer Thweatt
Jens Knudsen
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0047196
P407
P577
2012-01-01T00:00:00Z