about
The knockout mouse projectIsoprenylcysteine carboxyl methyltransferase deficiency in miceChylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipaseThe arrestin domain-containing 3 protein regulates body mass and energy expenditureHuman CYP7A1 deficiency: progress and enigmasLamin B1 is required for mouse development and nuclear integrityTargeting protein prenylation in progeriaDisruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defectsA carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylationInactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skinGene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulationThe International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouseLipins, lipinopathies, and the modulation of cellular lipid storage and signalingCompromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibriumCircumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signalingDiscovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)JCL Roundtable: Hypertriglyceridemia due to defects in lipoprotein lipase functionESCRT-III dysfunction causes autophagosome accumulation and neurodegenerationHeterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de MeledaPerception and motivation in face recognition: a critical review of theories of the Cross-Race EffectPrelamin A farnesylation and progeroid syndromesFamilial hypobetalipoproteinemia associated with a mutant species of apolipoprotein B (B-46)Evidence that the low frequency antigen Orriss is part of the MN blood group systemNuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinasesAgpat6 deficiency causes subdermal lipodystrophy and resistance to obesityHeterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient miceD-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient miceApobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expressionN-myristoyltransferase 1 is essential in early mouse developmentA gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B geneAgpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epitheliumTargeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in micePrenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liverTargeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cellsDefining the importance of phosphatidylserine synthase 2 in miceDual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob geneSEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.Biventricular adaptation to volume overload in mice with aortic regurgitation.Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria.
P50
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P50
description
researcher ORCID ID = 0000-0001-7270-3176
@en
wetenschapper
@nl
name
Stephen G. Young
@ast
Stephen G. Young
@en
Stephen G. Young
@nl
type
label
Stephen G. Young
@ast
Stephen G. Young
@en
Stephen G. Young
@nl
prefLabel
Stephen G. Young
@ast
Stephen G. Young
@en
Stephen G. Young
@nl
P31
P496
0000-0001-7270-3176