The physical relationship between infectivity and prion protein aggregates is strain-dependent
about
The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of diseasePrion pathogenesis in the absence of NLRP3/ASC inflammasomesTransgenic Rabbits Expressing Ovine PrP Are Susceptible to ScrapieEx vivo mammalian prions are formed of paired double helical prion protein fibrils.Biochemical properties of highly neuroinvasive prion strainsPrion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuICDefining the conformational features of anchorless, poorly neuroinvasive prionsIsolation of proteinase K-sensitive prions using pronase E and phosphotungstic acidAnalysis of Conformational Stability of Abnormal Prion Protein Aggregates across the Spectrum of Creutzfeldt-Jakob Disease PrionsNLRP3 Inflammasome in Neurological Diseases, from Functions to TherapiesNLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity.Enhanced neuroinvasion by smaller, soluble prions.High-resolution structure of infectious prion protein: the final frontierAtypical/Nor98 scrapie infectivity in sheep peripheral tissues.A simple, versatile and sensitive cell-based assay for prions from various speciesAccelerated, spleen-based titration of variant Creutzfeldt-Jakob disease infectivity in transgenic mice expressing human prion protein with sensitivity comparable to that of survival time bioassay.Prions in the urine of patients with variant Creutzfeldt-Jakob disease.Transmissibility of caprine scrapie in ovine transgenic mice.Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplificationStructure-based drug design identifies polythiophenes as antiprion compounds.Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain.Recovery of small infectious PrP(res) aggregates from prion-infected cultured cells.Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic micePlasminogen-based capture combined with amplification technology for the detection of PrP(TSE) in the pre-clinical phase of infectionQuaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.Insights into prion biology: integrating a protein misfolding pathway with its cellular environment.Mammalian prions: tracking the infectious entitiesInteraction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases.A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.Interaction between Shadoo and PrP Affects the PrP-Folding PathwayPrion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity.Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.PrPSc formation and clearance as determinants of prion tropism.Prion Infectivity Plateaus and Conversion to Symptomatic Disease Originate from Falling Precursor Levels and Increased Levels of Oligomeric PrPSc Species.Use of murine bioassay to resolve ovine transmissible spongiform encephalopathy cases showing a bovine spongiform encephalopathy molecular profile.Prions, proteinase K and infectivity.Fast and ultrasensitive method for quantitating prion infectivity titre.Mutated but Not Deleted Ovine PrP(C) N-Terminal Polybasic Region Strongly Interferes with Prion Propagation in Transgenic MiceSelective amplification of classical and atypical prions using modified protein misfolding cyclic amplification.Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions.
P2860
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P2860
The physical relationship between infectivity and prion protein aggregates is strain-dependent
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2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
The physical relationship betw ...... aggregates is strain-dependent
@ast
The physical relationship betw ...... aggregates is strain-dependent
@en
The physical relationship betw ...... aggregates is strain-dependent
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label
The physical relationship betw ...... aggregates is strain-dependent
@ast
The physical relationship betw ...... aggregates is strain-dependent
@en
The physical relationship betw ...... aggregates is strain-dependent
@nl
prefLabel
The physical relationship betw ...... aggregates is strain-dependent
@ast
The physical relationship betw ...... aggregates is strain-dependent
@en
The physical relationship betw ...... aggregates is strain-dependent
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P2093
P2860
P3181
P1433
P1476
The physical relationship betw ...... aggregates is strain-dependent
@en
P2093
Annick Le Dur
Emilie Jaumain
Fabienne Reine
Hubert Laude
Jérôme Chapuis
Laëtitia Herzog
Philippe Tixador
Vincent Béringue
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1000859
P407
P577
2010-04-01T00:00:00Z