De novo generation of infectious prions in vitro produces a new disease phenotype
about
Prion hypothesis: the end of the controversy?Darwinian evolution of prions in cell cultureIs tau ready for admission to the prion club?Recombinant prion protein induces a new transmissible prion disease in wild-type animals.Insoluble cellular prion protein and its association with prion and Alzheimer diseasesHighly efficient protein misfolding cyclic amplificationIntraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian PrionGenesis of mammalian prions: from non-infectious amyloid fibrils to a transmissible prion diseaseA brief history of prionsDe novo generation of prion strainsUltra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technologyDetection of PrPres in genetically susceptible fetuses from sheep with natural scrapiePrion formation, but not clearance, is supported by protein misfolding cyclic amplification.Detection of sub-clinical CWD infection in conventional test-negative deer long after oral exposure to urine and feces from CWD+ deer.Detection of protease-resistant cervid prion protein in water from a CWD-endemic areaProtein misfolding cyclic amplification of infectious prions.Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress.Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactorsIn vitro amplification of misfolded prion protein using lysate of cultured cells.Spontaneous generation of mammalian prionsDe novo prions.Comparison of 2 synthetically generated recombinant prions.Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplificationSmall protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).Prions.Immunomodulation for prion and prion-related diseases.Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prionsFactors affecting the accuracy of urine-based biomarkers of BSEEvidence of effective scrapie transmission via colostrum and milk in sheep.Peculiarities of prion diseasesIn vitro generation of high-titer prionsSalivary prions in sheep and deerIntracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.Stabilization of a prion strain of synthetic origin requires multiple serial passagesIsolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins.Protein misfolding cyclic amplification of prions.Identification of misfolded proteins in body fluids for the diagnosis of prion diseases.Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies.Ethics in prion disease.De novo generation of infectious prions with bacterially expressed recombinant prion protein.
P2860
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P2860
De novo generation of infectious prions in vitro produces a new disease phenotype
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
De novo generation of infectious prions in vitro produces a new disease phenotype
@ast
De novo generation of infectious prions in vitro produces a new disease phenotype
@en
De novo generation of infectious prions in vitro produces a new disease phenotype
@nl
type
label
De novo generation of infectious prions in vitro produces a new disease phenotype
@ast
De novo generation of infectious prions in vitro produces a new disease phenotype
@en
De novo generation of infectious prions in vitro produces a new disease phenotype
@nl
prefLabel
De novo generation of infectious prions in vitro produces a new disease phenotype
@ast
De novo generation of infectious prions in vitro produces a new disease phenotype
@en
De novo generation of infectious prions in vitro produces a new disease phenotype
@nl
P2093
P2860
P1433
P1476
De novo generation of infectious prions in vitro produces a new disease phenotype
@en
P2093
Abhisek Mukherjee
Claudio Soto
Dennisse Gonzalez-Romero
Marcelo A Barria
Rodrigo Morales
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000421
P407
P577
2009-05-01T00:00:00Z