Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process
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The cellular and molecular basis for malaria parasite invasion of the human red blood cellMerozoite surface proteins in red blood cell invasion, immunity and vaccines against malariaPfRH2b specific monoclonal antibodies inhibit merozoite invasionProtein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasiteDistinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasitesPlasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human ErythrocytesAn essential malaria protein defines the architecture of blood-stage and transmission-stage parasites.Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytesTime-lapse imaging of red blood cell invasion by the rodent malaria parasite Plasmodium yoeliiHost cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptideBabesia divergensandNeospora caninumapical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasionToxoplasma gondii Sporozoites Invade Host Cells Using Two Novel Paralogues of RON2 and AMA1Analyses of interactions between heparin and the apical surface proteins of Plasmodium falciparumA Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan GenesApical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion.The Binding of Plasmodium falciparum Adhesins and Erythrocyte Invasion Proteins to Aldolase Is Enhanced by PhosphorylationInteractions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cellsBinding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion.Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparumHumoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity.Signal integration by lipid-mediated spatial cross talk between Ras nanoclustersPeptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residuesInteraction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites.Non-apical membrane antigen 1 (AMA1) IgGs from Malian children interfere with functional activity of AMA1 IgGs as judged by growth inhibition assay.Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodiesIntramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyteToxoplasma gondii transmembrane microneme proteins and their modular design.Plant-based production of recombinant Plasmodium surface protein pf38 and evaluation of its potential as a vaccine candidate.Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevents host invasion of divergent plasmodial species.Expression, Purification, and Biological Characterization of Babesia microti Apical Membrane Antigen 1.Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum.Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic TailCharacterization of a novel inhibitory human monoclonal antibody directed against Plasmodium falciparum Apical Membrane Antigen 1.The malaria merozoite, forty years on.Blood-stage malaria vaccines - recent progress and future challenges.Invasion factors are coupled to key signalling events leading to the establishment of infection in apicomplexan parasites.The moving junction of apicomplexan parasites: a key structure for invasion.Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.Host-parasite interactions that guide red blood cell invasion by malaria parasites.
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P2860
Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process
description
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
article scientifique (publié 2009-03)
@fr
articolo scientifico (pubblicato il 2009-03)
@it
artigo científico (publicado na 2009-03)
@pt
artículu científicu espublizáu en 2009
@ast
im März 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: March 2009)
@en
vedecký článok (publikovaný 2009-03)
@sk
vetenskaplig artikel (publicerad på 2009-03)
@sv
name
Functional analysis of the lea ...... domain in the invasion process
@ast
Functional analysis of the lea ...... domain in the invasion process
@en
Functional analysis of the lea ...... domain in the invasion process
@nl
type
label
Functional analysis of the lea ...... domain in the invasion process
@ast
Functional analysis of the lea ...... domain in the invasion process
@en
Functional analysis of the lea ...... domain in the invasion process
@nl
prefLabel
Functional analysis of the lea ...... domain in the invasion process
@ast
Functional analysis of the lea ...... domain in the invasion process
@en
Functional analysis of the lea ...... domain in the invasion process
@nl
P2093
P2860
P50
P3181
P1433
P1476
Functional analysis of the lea ...... domain in the invasion process
@en
P2093
Ana Cabrera
Klemens Engelberg
Kota Miura
Nicole S Struck
Silvia Haase
Sonja Zacherl
Tim W Gilberger
Tobias Spielmann
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1000322
P407
P577
2009-03-01T00:00:00Z