Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele
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ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitroReduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brainCerebrovascular disease in ageing and Alzheimer's diseaseVasculoprotection as a Convergent, Multi-Targeted Mechanism of Anti-AD Therapeutics and InterventionsImpaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1Clearance systems in the brain-implications for Alzheimer diseaseVascular, glial, and lymphatic immune gateways of the central nervous systemCerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's diseaseLRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.Contributions and complexities from the use of in vivo animal models to improve understanding of human neuroimaging signals.White matter changes in dementia: role of impaired drainage of interstitial fluid.Imaging the Perivascular Space as a Potential Biomarker of Neurovascular and Neurodegenerative Diseases.Pulsed ultrasound expands the extracellular and perivascular spaces of the brainClinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically verified Alzheimer disease.Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloidApolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohortThe overlap between vascular disease and Alzheimer's disease--lessons from pathology.Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal proteaseMechanisms of fluid movement into, through and out of the brain: evaluation of the evidence.Modeling the Role of the Glymphatic Pathway and Cerebral Blood Vessel Properties in Alzheimer's Disease Pathogenesis.APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo.Cerebral white matter lesions - associations with Aβ isoforms and amyloid PETRegulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory diseaseIncreased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat dietLevels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samplesImpact of lifestyle dimensions on brain pathology and cognition.Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy.Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathyThe role of APOE in cerebrovascular dysfunctionInsulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's diseaseGlymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.Review: cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy.Drainage of cells and soluble antigen from the CNS to regional lymph nodes.Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk.The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy.Cerebral amyloid angiopathy, subcortical white matter disease and dementia: literature review and study in OPTIMA.The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.Metabolite Clearance During Wakefulness and Sleep.
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P2860
Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@ast
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@en
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@nl
type
label
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@ast
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@en
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@nl
prefLabel
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@ast
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@en
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@nl
P2093
P2860
P3181
P1433
P1476
Disruption of arterial perivas ...... ssing the human APOE ε4 allele
@en
P2093
Patrick M Sullivan
Roxana O Carare
Roy O Weller
Sarah Hands
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0041636
P407
P577
2012-07-25T00:00:00Z