TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans
about
RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress responseHeritable transmission of stress resistance by high dietary glucose in Caenorhabditis elegansMechanisms of aging-related proteinopathies in Caenorhabditis elegansExpression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in ratsHu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis.TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons.TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegansActivation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the MutationTDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.Disease animal models of TDP-43 proteinopathy and their pre-clinical applications.TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update.Aging, protein aggregation, chaperones, and neurodegenerative disorders: mechanisms of coupling and therapeutic opportunities.Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans.Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.TDP-43 in the spectrum of MND-FTLD pathologies.FET proteins regulate lifespan and neuronal integrity.Deciphering genetic interactions between ALS genes using C. elegans.Methylene blue rescues heart defects in a Drosophila model of Friedreich's ataxia.Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.
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P2860
TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@ast
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@en
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@nl
type
label
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@ast
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@en
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@nl
prefLabel
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@ast
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@en
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@nl
P2093
P2860
P50
P3181
P1433
P1476
TDP-1/TDP-43 regulates stress ...... city in Caenorhabditis elegans
@en
P2093
J Alex Parker
Peter E A Ash
Yari Carlomagno
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1002806
P407
P577
2012-07-01T00:00:00Z