ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.
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The formation and function of ER-endosome membrane contact sitesThere's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative DiseasesMitochondria-associated membranes as hubs for neurodegenerationGolgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport VesiclesThe different facets of organelle interplay-an overview of organelle interactionsOxidative stress and mitochondrial damage: importance in non-SOD1 ALSComputational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response.Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerabilitySen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiaeA combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decayExploring new pathways of neurodegeneration in ALS: the role of mitochondria quality controlMitochondrial lipids in neurodegenerationActivation of a cryptic splice site in the mitochondrial elongation factor GFM1 causes combined OXPHOS deficiency.Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylationProtein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivoPathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP productionThe BioPlex Network: A Systematic Exploration of the Human InteractomeNetwork analyses reveal novel aspects of ALS pathogenesisPPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43.A fungal sarcolemmal membrane-associated protein (SLMAP) homolog plays a fundamental role in development and localizes to the nuclear envelope, endoplasmic reticulum, and mitochondriaPreferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo.Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALSIRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.Of yeast, mice and men: MAMs come in two flavors.PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction.The pollen tube clear zone: clues to the mechanism of polarized growth.Mitochondrial dynamism and the pathogenesis of Amyotrophic Lateral Sclerosis.Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis.A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.The Role of TDP-43 in Alzheimer's Disease.Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling.ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained.Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson's Disease.Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51).Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology.Cysteine Modifications in the Pathogenesis of ALS.
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ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
ER-mitochondria associations a ...... by ALS/FTD-associated TDP-43.
@en
type
label
ER-mitochondria associations a ...... by ALS/FTD-associated TDP-43.
@en
prefLabel
ER-mitochondria associations a ...... by ALS/FTD-associated TDP-43.
@en
P2093
P2860
P50
P356
P1476
ER-mitochondria associations a ...... by ALS/FTD-associated TDP-43.
@en
P2093
Christopher C J Miller
Gema Vizcay-Barrena
Jacqueline C Mitchell
Jada Lewis
Radu Stoica
Rosa M Sancho
Sarah Mueller
Sébastien Paillusson
Wen-Lang Lin
P2860
P2888
P356
10.1038/NCOMMS4996
P407
P577
2014-06-03T00:00:00Z
P5875
P6179
1043509828