ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. - Test2 - elhamkhani - TriplyDB

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

http://www.wikidata.org/entity/Q38988714

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The formation and function of ER-endosome membrane contact sites There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases Mitochondria-associated membranes as hubs for neurodegeneration Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles The different facets of organelle interplay-an overview of organelle interactions Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response.Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerability Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control Mitochondrial lipids in neurodegeneration Activation of a cryptic splice site in the mitochondrial elongation factor GFM1 causes combined OXPHOS deficiency.Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production The BioPlex Network: A Systematic Exploration of the Human Interactome Network analyses reveal novel aspects of ALS pathogenesis PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43.A fungal sarcolemmal membrane-associated protein (SLMAP) homolog plays a fundamental role in development and localizes to the nuclear envelope, endoplasmic reticulum, and mitochondria Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo.Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.Of yeast, mice and men: MAMs come in two flavors.PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction.The pollen tube clear zone: clues to the mechanism of polarized growth.Mitochondrial dynamism and the pathogenesis of Amyotrophic Lateral Sclerosis.Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis.A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.The Role of TDP-43 in Alzheimer's Disease.Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling.ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained.Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson's Disease.Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51).Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology.Cysteine Modifications in the Pathogenesis of ALS.

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ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

http://www.wikidata.org/entity/Q38988714

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ER-mitochondria associations a ...... by ALS/FTD-associated TDP-43.

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Christopher C J Miller

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Gema Vizcay-Barrena

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Jacqueline C Mitchell

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Jada Lewis

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Radu Stoica

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Rosa M Sancho

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Sarah Mueller

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Sébastien Paillusson

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Wen-Lang Lin

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Ya-Fei Xu

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P2860

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2

Autophagosomes form at ER-mitochondria contact sites

Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels

An ER-mitochondria tethering complex revealed by a synthetic biology screen

MAM: more than just a housekeeper

The axonal transport of mitochondria

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans

The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections

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10.1038/NCOMMS4996

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5

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Dennis W. Dickson

Leonard Petrucelli

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2014-06-03T00:00:00Z

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262816008

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1043509828

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24893131

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amyotrophic lateral sclerosis

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4046113

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