Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.
about
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signalingDRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKRNonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosisHepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell linesISG56 and IFITM1 proteins inhibit hepatitis C virus replicationThe arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.Antiviral actions of interferonsAlpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replicationPhosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replicationHepatitis C virus proteinsInhibition of interferon signaling by dengue virusPathogen recognition and inflammatory signaling in innate immune defensesImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionPhosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcriptionOncogenes: The Passport for Viral Oncolysis Through PKR InhibitionHepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagyRegulation of hepatic innate immunity by hepatitis C virusHepatitis C virus infection and type 1 and type 2 diabetes mellitusHepatitis C virus molecular evolution: transmission, disease progression and antiviral therapyInnate immune responses in hepatitis C virus infectionProspective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapyModulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4BExpression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesisEvolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapyAntiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinaseExpression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathwayHyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyproteinTranscriptional Activation of the Interleukin-2 Promoter by Hepatitis C Virus Core ProteinCharacterization of cell lines carrying self-replicating hepatitis C virus RNAs.Mutations in Hepatitis C Virus RNAs Conferring Cell Culture AdaptationEnhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response.Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of FlavivirusesDNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection.Regulation of mRNA Translation and Cellular Signaling by Hepatitis C Virus Nonstructural Protein NS5ASequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.Activation of the interferon-inducible 2'-5'-oligoadenylate synthetase gene by hepatitis C virus core proteinDengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion.Persistent and transient replication of full-length hepatitis C virus genomes in cell culture
P2860
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P2860
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Control of PKR protein kinase ...... echanisms of kinase regulation
@nl
Control of PKR protein kinase ...... chanisms of kinase regulation.
@ast
Control of PKR protein kinase ...... chanisms of kinase regulation.
@en
type
label
Control of PKR protein kinase ...... echanisms of kinase regulation
@nl
Control of PKR protein kinase ...... chanisms of kinase regulation.
@ast
Control of PKR protein kinase ...... chanisms of kinase regulation.
@en
prefLabel
Control of PKR protein kinase ...... echanisms of kinase regulation
@nl
Control of PKR protein kinase ...... chanisms of kinase regulation.
@ast
Control of PKR protein kinase ...... chanisms of kinase regulation.
@en
P2093
P2860
P3181
P356
P1476
Control of PKR protein kinase ...... chanisms of kinase regulation.
@en
P2093
B Kwieciszewski
C M Blakely
D R Gretch
S J Polyak
P2860
P304
P3181
P356
10.1128/MCB.18.9.5208
P407
P577
1998-09-01T00:00:00Z