Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
about
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signalingIdentification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3Detection of a novel unglycosylated form of hepatitis C virus E2 envelope protein that is located in the cytosol and interacts with PKRNonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activationThe hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosisProtein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERKNew antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replicationHepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell linesPolo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5ARegulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPKHuman VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5BHepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagationThe arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complexHepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathwayAntiviral actions of interferonsPhosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replicationImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionInvolvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a vaccinia virus recombinantLinks between Human LINE-1 Retrotransposons and Hepatitis Virus-Related Hepatocellular CarcinomaHepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagyRegulation of hepatic innate immunity by hepatitis C virusViral quasispecies evolutionInnate immune responses in hepatitis C virus infectionCoronavirus gene 7 counteracts host defenses and modulates virus virulenceProspective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapyModulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4BControl of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutationsThe NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinasesGenetic heterogeneity of hypervariable region 1 of the hepatitis C virus (HCV) genome and sensitivity of HCV to alpha interferon therapy.Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesisEvolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapyAntiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinaseExpression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathwayHyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyproteinTranscriptional Activation of the Interleukin-2 Promoter by Hepatitis C Virus Core Protein
P2860
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P2860
Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@ast
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@en
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@en-gb
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@nl
type
label
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@ast
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@en
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@en-gb
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@nl
prefLabel
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@ast
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@en
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@en-gb
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@nl
P2093
P3181
P356
P1433
P1476
Evidence that hepatitis C viru ...... y the nonstructural 5A protein
@en
P2093
D A Hopkins
D R Gretch
S J Polyak
P304
P3181
P356
10.1006/VIRO.1997.8493
P407
P50
P577
1997-04-14T00:00:00Z