The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
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The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5ACellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A proteinInvolvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A proteinThe polypyrimidine tract-binding protein is required for efficient dengue virus propagation and associates with the viral replication machineryStructures of hepatitis C virus nonstructural proteins required for replicase assembly and functionAnalysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population LevelEffects of Mutagenic and Chain-Terminating Nucleotide Analogs on Enzymes Isolated from Hepatitis C Virus Strains of Various GenotypesCoordinated evolution of the hepatitis C virusStructural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA ReplicationThe NS4A Protein of Hepatitis C Virus Promotes RNA-Coupled ATP Hydrolysis by the NS3 HelicaseCyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymeraseHelicase inhibitors as specifically targeted antiviral therapy for hepatitis CHepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme ComplexesA Novel Class of meso-Tetrakis-Porphyrin Derivatives Exhibits Potent Activities against Hepatitis C Virus Genotype 1b Replicons In VitroHepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteinsPhylogenetic and 2D/3D Analysis of HCV 1a NS4A Gene/Protein in Pakistani Isolates.Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus.Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action.Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV)A cell culture adapted HCV JFH1 variant that increases viral titers and permits the production of high titer infectious chimeric reporter viruses.Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase.A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication.A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis.Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor.Post-translational modifications of hepatitis C viral proteins and their biological significance.Cellular and molecular biology of HCV infection and hepatitis.Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain.Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.Update on the Development of Anti-Viral Agents Against Hepatitis C.Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus ProductionThe HepaRG cell line: a valuable in vitro tool for hepatitis virus infection studies.ACH-806, an NS4A antagonist, inhibits hepatitis C virus replication by altering the composition of viral replication complexesTARGETING THE NS5A PROTEIN OF HCV: AN EMERGING OPTION.Structural and functional parameters of the flaviviral protease: a promising antiviral drug target.The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly.Phylogenetic and structural analysis of HCV nonstructural protein 4A from Pakistani patients.The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate.
P2860
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P2860
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@ast
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@en
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@nl
type
label
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@ast
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@en
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@nl
prefLabel
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@ast
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@en
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@nl
P2093
P2860
P356
P1433
P1476
The C Terminus of Hepatitis C ...... rylation and Viral Replication
@en
P2093
Anna M Pyle
Brett D Lindenbach
Béla M Prágai
Charles M Rice
Rudolf K F Beran
P2860
P304
P356
10.1128/JVI.00937-07
P577
2007-09-01T00:00:00Z