The Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious Virus
about
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5AA host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle productionGenetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine DesignTrafficking of hepatitis C virus core protein during virus particle assemblyHepatitis C virus NS4B carboxy terminal domain is a membrane binding domainFormation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B proteinMutations in Classical Swine Fever Virus NS4B Affect Virulence in SwineInduction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4BHCV core residues critical for infectivity are also involved in core-NS5A complex formationA new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutantsHepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteinsA comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins.Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B proteinUltrastructural and biophysical characterization of hepatitis C virus particles produced in cell cultureRapid intracellular competition between hepatitis C viral genomes as a result of mitosis.NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly.Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection.Increasing rate of cleavage at boundary between non-structural proteins 4B and 5A inhibits replication of hepatitis C virus.Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4BAminoterminal amphipathic α-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production.hepatitis c Virus p7 is critical for capsid assembly and envelopmentHepatitis C virus virology and new treatment targets.Genetic complementation of hepatitis C virus nonstructural protein functions associated with replication exhibits requirements that differ from those for virion assembly.Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replicationNS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes.Charged residues in hepatitis C virus NS4B are critical for multiple NS4B functions in RNA replication.Identification of AP80978, a novel small-molecule inhibitor of hepatitis C virus replication that targets NS4B.Impact of the autophagy machinery on hepatitis C virus infection.Lipid metabolism and HCV infectionA genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virusEncoded library technology screening of hepatitis C virus NS4B yields a small-molecule compound series with in vitro replicon activity.The interaction between the hepatitis C proteins NS4B and NS5A is involved in viral replicationDetergent-resistant membrane association of NS2 and E2 during hepatitis C virus replicationDynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus InfectionAAM-B Interacts with Nonstructural 4B and Regulates Hepatitis C Virus Propagation.Involvement of the 3' Untranslated Region in Encapsidation of the Hepatitis C VirusRobust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis.Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways.
P2860
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P2860
The Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious Virus
description
2009 nî lūn-bûn
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2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@ast
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@en
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@nl
type
label
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@ast
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@en
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@nl
prefLabel
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@ast
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@en
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@nl
P2860
P356
P1433
P1476
The Hepatitis C Virus NS4B Pro ...... Production of Infectious Virus
@en
P2093
Arvind H Patel
Daniel M Jones
P2860
P304
P356
10.1128/JVI.01885-08
P577
2009-03-01T00:00:00Z