Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly - Test2 - elhamkhani - TriplyDB

Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly

Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly

http://www.wikidata.org/entity/Q27488261

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Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2 Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection.Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication trans-Complementation of an NS2 Defect in a Late Step in Hepatitis C Virus (HCV) Particle Assembly and Maturation Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics Hepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes Naturally Occurring Hepatitis C Virus Subgenomic Deletion Mutants Replicate Efficiently in Huh-7 Cells and Are trans-Packaged In Vitro To Generate Infectious Defective Particles Characterization of Determinants Important for Hepatitis C Virus p7 Function in Morphogenesis by Using trans-Complementation Determinants of the Hepatitis C Virus Nonstructural Protein 2 Protease Domain Required for Production of Infectious Virus Structural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion Assembly NS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane Topologies The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins.Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly.Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription.A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly.Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.Identification of a functional, CRM-1-dependent nuclear export signal in hepatitis C virus core protein The core protein of classical Swine Fever virus is dispensable for virus propagation in vitro Hepatitis C virus experimental model systems and antiviral drug research.Picornavirus morphogenesis.NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system.Insights into the complexity and functionality of hepatitis C virus NS5A phosphorylation.Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome.Potential treatment options and future research to increase hepatitis C virus treatment response rate Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase.Production of hepatitis C virus lacking the envelope-encoding genes for single-cycle infection by providing homologous envelope proteins or vesicular stomatitis virus glycoproteins in trans.Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations.Identification of HNRNPK as regulator of hepatitis C virus particle production.Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes.The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation Last stop before exit - hepatitis C assembly and release as antiviral drug targets.Impact of the autophagy machinery on hepatitis C virus infection.A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication.Pestivirus virion morphogenesis in the absence of uncleaved nonstructural protein 2-3

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P2860

Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly

http://www.wikidata.org/entity/Q27488261

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2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Structural and Functional Char ...... in Hepatitis C Virus Assembly

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Structural and Functional Char ...... in Hepatitis C Virus Assembly

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Structural and Functional Char ...... in Hepatitis C Virus Assembly

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Anne Janvier

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Christiane Brohm

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Francois Penin

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Leah Eustachi

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Nicole Appel

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Thomas Pietschmann

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Vlastimil Jirasko

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P2860

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis

Characterization of an autonomous subgenomic pestivirus RNA replicon

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

A Natural Intergenotypic Recombinant of Hepatitis C Virus Identified in St. Petersburg

Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication.

Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras

Identification of a Naturally Occurring Recombinant Genotype 2/6 Hepatitis C Virus

Differential Biophysical Properties of Infectious Intracellular and Secreted Hepatitis C Virus Particles

Serendipitous identification of natural intergenotypic recombinants of hepatitis C in Ireland

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28546-62

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scholarly article

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1478035

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10.1074/JBC.M803981200

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42

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283

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Ralf Bartenschlager

Roland Montserret

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2008-10-17T00:00:00Z

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18644781

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2661407

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