trans-Complementation of an NS2 Defect in a Late Step in Hepatitis C Virus (HCV) Particle Assembly and Maturation
about
A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle productionSignal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle productionDirect acting antivirals for the treatment of chronic viral hepatitisHepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme ComplexesGenetic Analysis of the Carboxy-Terminal Region of the Hepatitis C Virus Core ProteinContribution of Genome-Wide HCV Genetic Differences to Outcome of Interferon-Based Therapy in Caucasian American and African American PatientsDrug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor bindingStructural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion AssemblyMolecular Mechanisms of Viral and Host Cell Substrate Recognition by Hepatitis C Virus NS3/4A ProteaseNS2 Proteins of GB Virus B and Hepatitis C Virus Share Common Protease Activities and Membrane TopologiesComparative Proteomics Reveals Important Viral-Host Interactions in HCV-Infected Human Liver CellsThe kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assemblyHepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteinsUltrastructural and biophysical characterization of hepatitis C virus particles produced in cell cultureNovel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studiesNS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly.Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection.Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription.A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly.The core protein of classical Swine Fever virus is dispensable for virus propagation in vitroNS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system.Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteinsProduction of hepatitis C virus lacking the envelope-encoding genes for single-cycle infection by providing homologous envelope proteins or vesicular stomatitis virus glycoproteins in trans.Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations.Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges.Identification of two internal signal peptide sequences: critical for classical swine fever virus non-structural protein 2 to trans-localize to the endoplasmic reticulum.Inhibition of hepatitis C virus production by aptamers against the core protein.Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translationThe subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 proteinInhibition of hepatitis C virus infection by DNA aptamer against NS2 protein.Last stop before exit - hepatitis C assembly and release as antiviral drug targets.Impact of the autophagy machinery on hepatitis C virus infection.A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication.Detergent-resistant membrane association of NS2 and E2 during hepatitis C virus replicationMorphogenesis of infectious hepatitis C virus particlesHepatitis C virus nonstructural protein 5B is involved in virus morphogenesis.A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis.Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis
P2860
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P2860
trans-Complementation of an NS2 Defect in a Late Step in Hepatitis C Virus (HCV) Particle Assembly and Maturation
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
trans-Complementation of an NS ...... rticle Assembly and Maturation
@ast
trans-Complementation of an NS ...... rticle Assembly and Maturation
@en
trans-Complementation of an NS ...... rticle Assembly and Maturation
@nl
type
label
trans-Complementation of an NS ...... rticle Assembly and Maturation
@ast
trans-Complementation of an NS ...... rticle Assembly and Maturation
@en
trans-Complementation of an NS ...... rticle Assembly and Maturation
@nl
altLabel
Trans-complementation of an NS ...... rticle assembly and maturation
@en
prefLabel
trans-Complementation of an NS ...... rticle Assembly and Maturation
@ast
trans-Complementation of an NS ...... rticle Assembly and Maturation
@en
trans-Complementation of an NS ...... rticle Assembly and Maturation
@nl
P2093
P2860
P3181
P1433
P1476
trans-Complementation of an NS ...... rticle Assembly and Maturation
@en
P2093
Jeremy Yates
MinKyung Yi
Stanley M Lemon
Yinghong Ma
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1000403
P407
P577
2009-05-01T00:00:00Z